Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Journal article


Publication Details

Author(s): Bowes J, Budu-Aggrey A, Hüffmeier U, Uebe S, Steel K, Hebert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, Mcmanus R, Fitzgerald O, Mchugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A
Journal: Nature Communications
Publication year: 2015
Volume: 6
Pages range: 6046
ISSN: 2041-1723


Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case-control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8(+) memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA.


FAU Authors / FAU Editors

Uebe, Steffen Dr. rer. nat.
Humangenetisches Institut


External institutions with authors

Adelaide and Meath Hospital
Goethe-Universität Frankfurt am Main
Monash University
National University of Ireland (NUI), Galway
Trinity College Dublin
Università degli Studi di Roma 'Tor Vergata'
University College Dublin (UCD)
University Hospital of Umeå / Norrlands universitetssjukhus (NUS)
University of Bath
University of Cambridge
University of Keele
University of Leeds
University of Manchester
University of Queensland


How to cite

APA:
Bowes, J., Budu-Aggrey, A., Hüffmeier, U., Uebe, S., Steel, K., Hebert, H.L.,... Barton, A. (2015). Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. Nature Communications, 6, 6046. https://dx.doi.org/10.1038/ncomms7046

MLA:
Bowes, John, et al. "Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis." Nature Communications 6 (2015): 6046.

BibTeX: 

Last updated on 2018-06-10 at 02:32