VCP and PSMF1: Antagonistic regulators of proteasome activity
Clemen CS, Marko M, Strucksberg KH, Behrens J, Wittig I, Gaertner L, Winter L, Chevessier F, Matthias J, Türk M, Tangavelou K, Schütz J, Arhzaouy K, Klopffleisch K, Hanisch FG, Rottbauer W, Blümcke I, Just S, Eichinger L, Hofmann A, Schröder R (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 463
Pages Range: 1210-7
Journal Issue: 4
DOI: 10.1016/j.bbrc.2015.06.086
Abstract
Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity.
Authors with CRIS profile
Matthias Türk
Lehrstuhl für Neuropathologie
Ingmar Blümcke
Lehrstuhl für Neuropathologie
Rolf Schröder
Professur für Neuropathologie
Involved external institutions
Universitätsklinikum Ulm
Germany (DE)
Universität zu Köln
Germany (DE)
Griffith University
Australia (AU)
Goethe-Universität Frankfurt am Main
Germany (DE)
Germany (DE)
Universität zu Köln
Germany (DE)
Griffith University
Australia (AU)
Goethe-Universität Frankfurt am Main
Germany (DE)
How to cite
APA:
Clemen, C.S., Marko, M., Strucksberg, K.-H., Behrens, J., Wittig, I., Gaertner, L.,... Schröder, R. (2015). VCP and PSMF1: Antagonistic regulators of proteasome activity. Biochemical and Biophysical Research Communications, 463(4), 1210-7. https://doi.org/10.1016/j.bbrc.2015.06.086
MLA:
Clemen, Christoph S., et al. "VCP and PSMF1: Antagonistic regulators of proteasome activity." Biochemical and Biophysical Research Communications 463.4 (2015): 1210-7.
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