Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Stone J, Thompson DJ, Silva IDS, Scott C, Tamimi RM, Lindstrom S, Kraft P, Hazra A, Li J, Eriksson L, Czene K, Hall P, Jensen M, Cunningham J, Olson JE, Purrington K, Couch FJ, Brown J, Leyland J, Warren RML, Luben RN, Khaw KT, Smith P, Wareham NJ, Jud S, Heusinger K, Beckmann M, Douglas JA, Shah KP, Chan HP, Helvie MA, Le Marchand L, Kolonel LN, Woolcott C, Maskarinec G, Haiman C, Giles GG, Baglietto L, Krishnan K, Southey MC, Apicella C, Andrulis IL, Knight JA, Ursin G, Alnaes GIG, Kristensen VN, Borresen-Dale AL, Gram IT, Bolla MK, Wang Q, Michailidou K, Dennis J, Simard J, Pharoah P, Dunning AM, Easton DF, Fasching P, Pankratz VS, Hopper JL, Vachon CM (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 75

Pages Range: 2457-67

Journal Issue: 12

DOI: 10.1158/0008-5472.CAN-14-2012

Abstract

Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk, but few mammographic density-associated genetic variants have been identified. Using data for 10,727 women from two international consortia, we estimated associations between 77 common breast cancer susceptibility variants and absolute dense area, percent dense area and absolute nondense area adjusted for study, age, and BMI using mixed linear modeling. We found strong support for established associations between rs10995190 (in the region of ZNF365), rs2046210 (ESR1), and rs3817198 (LSP1) and adjusted absolute and percent dense areas (all P < 10(-5)). Of 41 recently discovered breast cancer susceptibility variants, associations were found between rs1432679 (EBF1), rs17817449 (MIR1972-2: FTO), rs12710696 (2p24.1), and rs3757318 (ESR1) and adjusted absolute and percent dense areas, respectively. There were associations between rs6001930 (MKL1) and both adjusted absolute dense and nondense areas, and between rs17356907 (NTN4) and adjusted absolute nondense area. Trends in all but two associations were consistent with those for breast cancer risk. Results suggested that 18% of breast cancer susceptibility variants were associated with at least one mammographic density measure. Genetic variants at multiple loci were associated with both breast cancer risk and the mammographic density measures. Further understanding of the underlying mechanisms at these loci could help identify etiologic pathways implicated in how mammographic density predicts breast cancer risk.

Authors with CRIS profile

Involved external institutions

Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) University of Cambridge United Kingdom (GB) Mayo Clinic United States (USA) (US) The University of Melbourne Australia (AU) University of Western Australia (UWA) Australia (AU) London School of Hygiene and Tropical Medicine United Kingdom (GB) Brigham and Women's Hospital (BWH) United States (USA) (US) Wayne State University (WSU) United States (USA) (US) Harvard University United States (USA) (US) Karolinska Institute Sweden (SE) University of Michigan United States (USA) (US) University of Hawaii (U.H.) United States (USA) (US) Dalhousie University Canada (CA) University of Southern California (USC) United States (USA) (US) Cancer Council Victoria Australia (AU) Mount Sinai Hospital (MSH) Canada (CA) University of Oslo Norway (NO) Universitetet i Tromsø / The Arctic University of Norway (UiT) Norway (NO) Centre hospitalier universitaire de Québec Canada (CA)

How to cite

APA:

Stone, J., Thompson, D.J., Silva, I.D.S., Scott, C., Tamimi, R.M., Lindstrom, S.,... Vachon, C.M. (2015). Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures. Cancer Research, 75(12), 2457-67. https://doi.org/10.1158/0008-5472.CAN-14-2012

MLA:

Stone, Jennifer, et al. "Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures." Cancer Research 75.12 (2015): 2457-67.

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