Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium

Nagle CM, Dixon SC, Jensen A, Kjaer SK, Modugno F, Defazio A, Fereday S, Hung J, Johnatty SE, Fasching P, Beckmann M, Lambrechts D, Vergote I, Van Nieuwenhuysen E, Lambrechts S, Risch HA, Rossing MA, Doherty JA, Wicklund KG, Chang-Claude J, Goodman MT, Ness RB, Moysich K, Heitz F, Du Bois A, Harter P, Schwaab I, Matsuo K, Hosono S, Goode EL, Vierkant RA, Larson MC, Fridley BL, Hogdall C, Schildkraut JM, Weber RP, Cramer DW, Terry KL, Bandera EV, Paddock L, Rodriguez-Rodriguez L, Wentzensen N, Yang HP, Brinton LA, Lissowska J, Hogdall E, Lundvall L, Whittemore A, Mcguire V, Sieh W, Rothstein J, Sutphen R, Anton-Culver H, Ziogas A, Pearce CL, Wu AH, Webb PM (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 113

Pages Range: 817-26

Journal Issue: 5

DOI: 10.1038/bjc.2015.245

Abstract

Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among women with invasive ovarian cancer.We used original data from 21 studies, which included 12 390 women with ovarian carcinoma. We combined study-specific adjusted hazard ratios (HRs) using random-effects models to estimate pooled HRs (pHR). We further explored associations by histologic subtype.Overall, 6715 (54%) deaths occurred during follow-up. A significant OS disadvantage was observed for women who were obese (BMI: 30-34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99-1.23); BMI: ?35, pHR: 1.12 (95% CI: 1.01-1.25)). Results were similar for PFS and ovarian cancer-specific survival. In analyses stratified by histologic subtype, associations were strongest for women with low-grade serous (pHR: 1.12 per 5 kg m(-2)) and endometrioid subtypes (pHR: 1.08 per 5 kg m(-2)), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m(-2)) subtype, but only the association with high-grade serous cancers was significant.Higher BMI is associated with adverse survival among the majority of women with ovarian cancer.

Authors with CRIS profile

Involved external institutions

University of South Florida (USF) United States (USA) (US) University of California Irvine United States (USA) (US) University of Southern California (USC) United States (USA) (US) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) Danish Cancer Society Research Center Denmark (DK) University of Pittsburgh United States (USA) (US) Westmead Hospital Australia (AU) Peter MacCallum Cancer Centre Australia (AU) Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB) Belgium (BE) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Yale University United States (USA) (US) Fred Hutchinson Cancer Research Center Canada (CA) Dartmouth College United States (USA) (US) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Cedars-Sinai Medical Center United States (USA) (US) University of Texas MD Anderson Cancer Center United States (USA) (US) Roswell Park Cancer Institute United States (USA) (US) Kliniken Essen-Mitte Germany (DE) Institut für Humangenetik Wiesbaden Germany (DE) Kyushu University / 九州大学 Japan (JP) Aichi Cancer Center Research Institute Japan (JP) Mayo Clinic United States (USA) (US) University of Kansas (KU) United States (USA) (US) University of Copenhagen Denmark (DK) Duke University United States (USA) (US) Brigham and Women's Hospital (BWH) United States (USA) (US) University of Medicine and Dentistry of New Jersey (UMDNJ) United States (USA) (US) New Jersey, Department of Health United States (USA) (US) National Cancer Institute (NCI) United States (USA) (US) Stanford University United States (USA) (US) Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie Poland (PL)

How to cite

APA:

Nagle, C.M., Dixon, S.C., Jensen, A., Kjaer, S.K., Modugno, F., Defazio, A.,... Webb, P.M. (2015). Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium. British Journal of Cancer, 113(5), 817-26. https://doi.org/10.1038/bjc.2015.245

MLA:

Nagle, C. M., et al. "Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium." British Journal of Cancer 113.5 (2015): 817-26.

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