Population distribution of lifetime risk of ovarian cancer in the United States

Pearce CL, Stram DO, Ness RB, Stram DA, Roman LD, Templeman C, Lee AW, Menon U, Fasching P, Mcalpine JN, Doherty JA, Modugno F, Schildkraut JM, Rossing MA, Huntsman DG, Wu AH, Berchuck A, Pike MC, Pharoah PDP (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Cancer Epidemiology Biomarkers & Prevention American Association for Cancer Research

Book Volume: 24

Pages Range: 671-6

Journal Issue: 4

DOI: 10.1158/1055-9965.EPI-14-1128

Abstract

In U.S. women, lifetime risk of ovarian cancer is 1.37%, but some women are at a substantially lower or higher risk than this average.We have characterized the distribution of lifetime risk in the general population. Published data on the relative risks and their variances for five well-accepted risk and protective factors for ovarian cancer, oral contraceptive use, parity, tubal ligation, endometriosis, and first-degree family history of ovarian cancer in conjunction with a genetic risk score using genome-wide significant common, low penetrance variants were used. The joint distribution of these factors (i.e., risk/protective factor profiles) was derived using control data from four U.S. population-based studies, providing a broad representation of women in the United States.A total of 214 combinations of risk/protective factors were observed, and the lifetime risk estimates ranged from 0.35% [95% confidence interval (CI), 0.29-0.42] to 8.78% (95% CI, 7.10-10.9). Among women with lifetime risk ranging from 4% to 9%, 73% had no family history of ovarian cancer; most of these women had a self-reported history of endometriosis.Profiles including the known modifiable protective factors of oral contraceptive use and tubal ligation were associated with a lower lifetime risk of ovarian cancer. Oral contraceptive use and tubal ligation were essentially absent among the women at 4% to 9% lifetime risk.This work demonstrates that there are women in the general population who have a much higher than average lifetime risk of ovarian cancer. Preventive strategies are available. Should effective screening become available, higher than average risk women can be identified.

Authors with CRIS profile

Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Duke University US United States (USA) (US) University of Cambridge GB United Kingdom (GB) University of Southern California (USC) US United States (USA) (US) University of British Columbia CA Canada (CA) Fred Hutchinson Cancer Research Center CA Canada (CA) University of Pittsburgh US United States (USA) (US) Dartmouth College US United States (USA) (US) University College London (UCL) GB United Kingdom (GB) University of Texas MD Anderson Cancer Center US United States (USA) (US) University of Michigan US United States (USA) (US)

How to cite

APA:

Pearce, C.L., Stram, D.O., Ness, R.B., Stram, D.A., Roman, L.D., Templeman, C.,... Pharoah, P.D.P. (2015). Population distribution of lifetime risk of ovarian cancer in the United States. Cancer Epidemiology Biomarkers & Prevention, 24(4), 671-6. https://doi.org/10.1158/1055-9965.EPI-14-1128

MLA:

Pearce, Celeste Leigh, et al. "Population distribution of lifetime risk of ovarian cancer in the United States." Cancer Epidemiology Biomarkers & Prevention 24.4 (2015): 671-6.

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