Feasibility of VECOPA, a dose-intensive chemotherapy regimen for children and adolescents with intermediate and advanced stage Hodgkin lymphoma: results of the GPOH-HD-2002/VECOPA pilot trial
Mauz-Koerholz C, Hasenclever D, Holzendorf V, Bernstaedt M, Juergens H, Burdach S, Eggert A, Berthold F, Mueller HL, Fruehwald MC, Klingebiel T, Metzler M, Koerholz D (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 56
Pages Range: 1308-14
Journal Issue: 5
DOI: 10.3109/10428194.2014.961011
Abstract
The GPOH-HD (Gesellschaft für Pädiatrische Onkologie und Hämatologie-Hodgkin Disease) strategy for children and adolescents with intermediate and advanced stage Hodgkin lymphoma is based on two induction cycles of OEPA (vincristine, etoposide, prednisone, doxorubicin) followed by COPP (cyclophosphamide, vincristine, procarbazine, prednisone) or COPDAC (cyclophosphamide, vincristine, prednisone, dacarbazine) consolidation. The feasibility and efficacy of an intensified procarbazine-free consolidation regimen VECOPA (vinblastine, etoposide, cyclophosphamide, vincristine, prednisone, doxorubicin) were investigated. Following two OEPA and one or two VECOPA cycles, involved field radiotherapy was applied. The main endpoint was feasibility. Secondary endpoints were toxicity, proportion of delayed cycles, granulocyte-colony stimulating factor use, and event-free and overall survival. The regimen was well tolerated with mostly hematotoxicity exceeding Common Toxicity Criteria grade 2. In most patients with advanced stage the second VECOPA cycle was delayed despite hematopoietic recovery and absence of serious adverse events. Event-free survival at 36 months was 0.86 (95% confidence interval 0.70-1). The VECOPA regimen is effective and tolerable. However, its time-intensification was not fully exploited within this trial.
Authors with CRIS profile
Markus Metzler
Professur für Kinder- und Jugendmedizin mit dem Schwerpunkt Pädiatrische Onkologie und Hämatologie
Involved external institutions
Klinikum Augsburg
Germany (DE)
Martin-Luther-Universität Halle-Wittenberg (MLU)
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Klinikum Oldenburg
Germany (DE)
Universität zu Köln
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
Universität Leipzig
Germany (DE)
Germany (DE)
Martin-Luther-Universität Halle-Wittenberg (MLU)
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Klinikum Oldenburg
Germany (DE)
Universität zu Köln
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
Universität Leipzig
Germany (DE)
How to cite
APA:
Mauz-Koerholz, C., Hasenclever, D., Holzendorf, V., Bernstaedt, M., Juergens, H., Burdach, S.,... Koerholz, D. (2015). Feasibility of VECOPA, a dose-intensive chemotherapy regimen for children and adolescents with intermediate and advanced stage Hodgkin lymphoma: results of the GPOH-HD-2002/VECOPA pilot trial. Leukemia & Lymphoma, 56(5), 1308-14. https://doi.org/10.3109/10428194.2014.961011
MLA:
Mauz-Koerholz, Christine, et al. "Feasibility of VECOPA, a dose-intensive chemotherapy regimen for children and adolescents with intermediate and advanced stage Hodgkin lymphoma: results of the GPOH-HD-2002/VECOPA pilot trial." Leukemia & Lymphoma 56.5 (2015): 1308-14.
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