Sodium chloride, SGK1, and Th17 activation

Beitrag in einer Fachzeitschrift
(Review-Artikel)


Details zur Publikation

Autorinnen und Autoren: Binger KJ, Linker R, Muller DN, Kleinewietfeld M
Zeitschrift: Pflugers Archiv-European Journal of Physiology
Jahr der Veröffentlichung: 2015
Band: 467
Heftnummer: 3
Seitenbereich: 543-50
ISSN: 0031-6768


Abstract


The incidence of autoimmune diseases in Western civilizations is increasing rapidly, suggesting an influence of environmental factors, such as diet. The pathogenesis of several of these autoimmune diseases is characterized by aberrant activation of T helper 17 (Th17) cells. Recent reports have shown that the differentiation of Th17 cells is sensitive to changes in local microenvironments, in particular salt (NaCl) concentrations, in a molecular mechanism centered around the serum- and glucocorticoid-inducible kinase 1 (SGK1). In this review, we summarize the recently disclosed mechanisms by which salt has been shown to affect SGK1 and, subsequently, Th17 activation.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Linker, Ralf PD Dr.
Stiftungsprofessur für Neuroimmunologie


Einrichtungen weiterer Autorinnen und Autoren

Experimental and Clinical Research Center (ECRC)
Technische Universität Dresden


Zitierweisen

APA:
Binger, K.J., Linker, R., Muller, D.N., & Kleinewietfeld, M. (2015). Sodium chloride, SGK1, and Th17 activation. Pflugers Archiv-European Journal of Physiology, 467(3), 543-50. https://dx.doi.org/10.1007/s00424-014-1659-z

MLA:
Binger, Katrina J., et al. "Sodium chloride, SGK1, and Th17 activation." Pflugers Archiv-European Journal of Physiology 467.3 (2015): 543-50.

BibTeX: 

Zuletzt aktualisiert 2018-06-10 um 02:17