The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases
Reijs BLR, Teunissen CE, Goncharenko N, Betsou F, Blennow K, Baldeiras I, Brosseron F, Cavedo E, Fladby T, Froelich L, Gabryelewicz T, Gurvit H, Kapaki E, Koson P, Kulic L, Lehmann S, Lewczuk P, Lleo A, Maetzler W, De Mendonca A, Miller AM, Molinuevo JL, Mollenhauer B, Parnetti L, Rot U, Schneider A, Simonsen AH, Tagliavini F, Tsolaki M, Verbeek MM, Verhey FRJ, Zboch M, Winblad B, Scheltens P, Zetterberg H, Visser PJ (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 6
Pages Range: 216
Abstract
Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank.
Authors with CRIS profile
Involved external institutions
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Germany (DE)
National and Kapodistrian University of Athens
Greece (GR)
Maastricht University
Netherlands (NL)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
Vrije Universiteit Amsterdam (VU) / University Amsterdam
Netherlands (NL)
Karolinska Institute
Sweden (SE)
Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu
Poland (PL)
Radboud University Nijmegen
Netherlands (NL)
Aristotle University of Thessaloniki
Greece (GR)
Foundation of the Carlo Besta Neurological Institute (IRCCS)
Italy (IT)
Copenhagen University Hospital
Denmark (DK)
Universitätsklinikum Göttingen
Germany (DE)
Ljubljana University Medical Centre (Ljubljana UMC) / Univerzitetni klinični center Ljubljana
Slovenia (SI)
Università degli Studi di Perugia
Italy (IT)
Paracelsus-Elena-Klinik Kassel
Germany (DE)
Hospital Clínic de Barcelona
Spain (ES)
Trinity College Dublin
Ireland (IE)
University of Lisbon / Universidade de Lisboa (ULisboa)
Portugal (PT)
Eberhard Karls Universität Tübingen
Germany (DE)
Hospital de la Santa Creu i Sant Pau
Spain (ES)
University of Montpellier / Université Montpellier
France (FR)
University of Zurich / Universität Zürich (UZH)
Switzerland (CH)
Slovak Medical University (SMU) / Slovenská zdravotnícka univerzita v Bratislave
Slovakia (SK)
Istanbul University / İstanbul Üniversitesi
Turkey (TR)
Polska Akademia Nauk (PAN) / Polish Academy of Sciences
Poland (PL)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Akershus University Hospital / Akershus universitetssykehus (Ahus)
Norway (NO)
IRCCS Fatebenefratelli - Brescia
Italy (IT)
Universidade de Coimbra
Portugal (PT)
Integrated Biobank of Luxembourg: IBBL
Luxembourg (LU)
Germany (DE)
National and Kapodistrian University of Athens
Greece (GR)
Maastricht University
Netherlands (NL)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
Vrije Universiteit Amsterdam (VU) / University Amsterdam
Netherlands (NL)
Karolinska Institute
Sweden (SE)
Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu
Poland (PL)
Radboud University Nijmegen
Netherlands (NL)
Aristotle University of Thessaloniki
Greece (GR)
Foundation of the Carlo Besta Neurological Institute (IRCCS)
Italy (IT)
Copenhagen University Hospital
Denmark (DK)
Universitätsklinikum Göttingen
Germany (DE)
Ljubljana University Medical Centre (Ljubljana UMC) / Univerzitetni klinični center Ljubljana
Slovenia (SI)
Università degli Studi di Perugia
Italy (IT)
Paracelsus-Elena-Klinik Kassel
Germany (DE)
Hospital Clínic de Barcelona
Spain (ES)
Trinity College Dublin
Ireland (IE)
University of Lisbon / Universidade de Lisboa (ULisboa)
Portugal (PT)
Eberhard Karls Universität Tübingen
Germany (DE)
Hospital de la Santa Creu i Sant Pau
Spain (ES)
University of Montpellier / Université Montpellier
France (FR)
University of Zurich / Universität Zürich (UZH)
Switzerland (CH)
Slovak Medical University (SMU) / Slovenská zdravotnícka univerzita v Bratislave
Slovakia (SK)
Istanbul University / İstanbul Üniversitesi
Turkey (TR)
Polska Akademia Nauk (PAN) / Polish Academy of Sciences
Poland (PL)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Akershus University Hospital / Akershus universitetssykehus (Ahus)
Norway (NO)
IRCCS Fatebenefratelli - Brescia
Italy (IT)
Universidade de Coimbra
Portugal (PT)
Integrated Biobank of Luxembourg: IBBL
Luxembourg (LU)
How to cite
APA:
Reijs, B.L.R., Teunissen, C.E., Goncharenko, N., Betsou, F., Blennow, K., Baldeiras, I.,... Visser, P.J. (2015). The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases. Frontiers in Neurology, 6, 216. https://doi.org/10.3389/fneur.2015.00216
MLA:
Reijs, Babette L. R., et al. "The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases." Frontiers in Neurology 6 (2015): 216.
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