Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, De Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl U, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueröder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van Den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 6

Pages Range: 588

DOI: 10.3389/fimmu.2015.00588

Abstract

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.

Authors with CRIS profile

Involved external institutions

Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) Universitätsklinikum Jena Germany (DE) Sotio as Czech Republic (CZ) Université de Montréal Canada (CA) Centre de Recherche des Cordeliers France (FR) Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB) Belgium (BE) Institut Gustave-Roussy France (FR) Università degli Studi della Tuscia Italy (IT) University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud France (FR) Institut Pasteur France (FR) Massachusetts General Hospital United States (USA) (US) Helsingin yliopisto / University of Helsinki Finland (FI) National Cancer Institute (NCI) United States (USA) (US) Université de Strasbourg (UDS) France (FR) Karl-Franzens-Universität Graz Austria (AT) Università Vita-Salute San Raffaele (UniSR) Italy (IT) University of Queensland Australia (AU) Technische Universität München (TUM) Germany (DE) Inselspital, Universitätsspital Bern Switzerland (CH) University of Nice Sophia Antipolis / Université Nice Sophia Antipolis France (FR) University of Turin / Università degli Studi di Torino (UNITO) Italy (IT) National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) France (FR) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) University of Medicine and Dentistry of New Jersey (UMDNJ) United States (USA) (US) Vrije Universiteit Brussel (VUB) Belgium (BE) University of Manchester United Kingdom (GB) Università degli studi "La Sapienza" Italy (IT) Université Catholique de Louvain (UCL) Belgium (BE) Università del Salento Italy (IT) Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu Poland (PL)

How to cite

APA:

Garg, A.D., Galluzzi, L., Apetoh, L., Baert, T., Birge, R.B., Bravo-San Pedro, J.M.,... Agostinis, P. (2015). Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Frontiers in Immunology, 6, 588. https://dx.doi.org/10.3389/fimmu.2015.00588

MLA:

Garg, Abhishek D., et al. "Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death." Frontiers in Immunology 6 (2015): 588.

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