Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, De Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl U, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueröder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van Den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P
Zeitschrift: Frontiers in Immunology
Jahr der Veröffentlichung: 2015
Band: 6
Seitenbereich: 588
ISSN: 1664-3224


Abstract


The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.



FAU-Autoren / FAU-Herausgeber

Gaipl, Udo Prof. Dr.
Strahlenklinik
Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Maueröder, Christian
Medizinische Klinik 3 - Rheumatologie und Immunologie


Autor(en) der externen Einrichtung(en)
Centre de Recherche des Cordeliers
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Helsingin yliopisto / University of Helsinki
Inselspital, Universitätsspital Bern
Institut Gustave-Roussy
Institut Pasteur
Karl-Franzens-Universität Graz
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Massachusetts General Hospital
National Cancer Institute (NCI)
National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM)
QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research)
Sotio as
Technische Universität München (TUM)
Università degli Studi della Tuscia
Università degli studi "La Sapienza"
Università del Salento
Universitätsklinikum Jena
Università Vita-Salute San Raffaele (UniSR)
Université Catholique de Louvain (UCL)
Université de Montréal
Université de Strasbourg (UDS)
Université Nice Sophia Antipolis / University of Nice Sophia Antipolis
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
University of Manchester
University of Medicine and Dentistry of New Jersey (UMDNJ)
University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud
University of Queensland
University of Turin / Università degli Studi di Torino (UNITO)
Vrije Universiteit Brussel
Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu


Zitierweisen

APA:
Garg, A.D., Galluzzi, L., Apetoh, L., Baert, T., Birge, R.B., Bravo-San Pedro, J.M.,... Agostinis, P. (2015). Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Frontiers in Immunology, 6, 588. https://dx.doi.org/10.3389/fimmu.2015.00588

MLA:
Garg, Abhishek D., et al. "Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death." Frontiers in Immunology 6 (2015): 588.

BibTeX: 

Zuletzt aktualisiert 2019-17-04 um 08:17