Scherer M, Stamminger T (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 90
Pages Range: 5850-4
Journal Issue: 13
DOI: 10.1128/JVI.01979-15
Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PML, hDaxx, Sp100, or ATRX protein, that are able to act as cellular restriction factors. Recent studies now reveal an emerging role of PML-NBs as coregulatory structures of both type I and type II interferon responses. This emphasizes that targeting of PML-NBs by viral regulatory proteins has evolved as a strategy to compromise intrinsic antiviral defense and innate immune responses.
APA:
Scherer, M., & Stamminger, T. (2016). Emerging Role of PML Nuclear Bodies in Innate Immune Signaling. Journal of Virology, 90(13), 5850-4. https://doi.org/10.1128/JVI.01979-15
MLA:
Scherer, Myriam, and Thomas Stamminger. "Emerging Role of PML Nuclear Bodies in Innate Immune Signaling." Journal of Virology 90.13 (2016): 5850-4.
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