Multiscale approaches to protein-mediated interactions between membranes-relating microscopic and macroscopic dynamics in radially growing adhesions

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autor(en): Bihr T, Seifert U, Smith AS
Zeitschrift: New Journal of Physics
Verlag: IOP PUBLISHING LTD
Jahr der Veröffentlichung: 2015
Band: 17
ISSN: 1367-2630


Abstract


Macromolecular complexation leading to coupling of two or more cellular membranes is a crucial step in a number of biological functions of the cell. While other mechanisms may also play a role, adhesion always involves the fluctuations of deformable membranes, the diffusion of proteins and the molecular binding and unbinding. Because these stochastic processes couple over a multitude of time and length scales, theoretical modeling of membrane adhesion has been a major challenge. Here we present an effective Monte Carlo scheme within which the effects of the membrane are integrated into local rates for molecular recognition. The latter step in the Monte Carlo approach enables us to simulate the nucleation and growth of adhesion domains within a system of the size of a cell for tens of seconds without loss of accuracy, as shown by comparison to 10(6) times more expensive Langevin simulations. To perform this validation, the Langevin approach was augmented to simulate diffusion of proteins explicitly, together with reaction kinetics and membrane dynamics. We use the Monte Carlo scheme to gain deeper insight to the experimentally observed radial growth of micron sized adhesion domains, and connect the effective rate with which the domain is growing to the underlying microscopic events. We thus demonstrate that our technique yields detailed information about protein transport and complexation in membranes, which is a fundamental step toward understanding even more complex membrane interactions in the cellular context.



FAU-Autoren / FAU-Herausgeber

Bihr, Timo
Professur für Theoretische Physik
Smith, Ana-Suncana Prof. Dr.
Professur für Theoretische Physik


Zusätzliche Organisationseinheit(en)
Exzellenz-Cluster Engineering of Advanced Materials


Autor(en) der externen Einrichtung(en)
Universität Stuttgart


Zitierweisen

APA:
Bihr, T., Seifert, U., & Smith, A.-S. (2015). Multiscale approaches to protein-mediated interactions between membranes-relating microscopic and macroscopic dynamics in radially growing adhesions. New Journal of Physics, 17. https://dx.doi.org/10.1088/1367-2630/17/8/083016

MLA:
Bihr, Timo, Udo Seifert, and Ana-Suncana Smith. "Multiscale approaches to protein-mediated interactions between membranes-relating microscopic and macroscopic dynamics in radially growing adhesions." New Journal of Physics 17 (2015).

BibTeX: 

Zuletzt aktualisiert 2018-10-08 um 17:08