PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Bowes J, Loehr S, Budu-Aggrey A, Uebe S, Bruce IN, Feletar M, Marzo-Ortega H, Helliwell P, Ryan AW, Kane D, Korendowych E, Alenius GM, Giardina E, Packham J, Mcmanus R, Fitzgerald O, Brown MA, Behrens F, Burkhardt H, Mchugh N, Hüffmeier U, Ho P, Reis A, Barton A
Zeitschrift: Annals of the Rheumatic Diseases
Jahr der Veröffentlichung: 2015
Band: 74
Heftnummer: 10
Seitenbereich: 1882-5
ISSN: 0003-4967


Abstract


Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA.A total of 15 single nucleotide polymorphisms were selected (PImmunochip <1×10(-4)) for validation genotyping in 1177 cases and 2155 controls using TaqMan. Meta-analysis of Immunochip and validation data sets consisted of 3139 PsA cases and 11 078 controls. Novel PsA susceptibility loci were compared with data from two large psoriasis studies (WTCCC2 and Immunochip) to determine PsA specificity.We found genome-wide significant association to rs2476601, mapping to PTPN22 (p=1.49×10(-9), OR=1.32), but no evidence for association in the psoriasis cohort (p=0.34) and the effect estimates were significantly different between PsA and psoriasis (p=3.2×10(-4)). Additionally, we found genome-wide significant association to the previously reported psoriasis risk loci; NOS2 (rs4795067, p=5.27×10(-9)).For the first time, we report genome-wide significant association of PTPN22 (rs2476601) to PsA susceptibility, but no evidence for association to psoriasis.



FAU-Autoren / FAU-Herausgeber

Uebe, Steffen Dr. rer. nat.
Humangenetisches Institut


Autor(en) der externen Einrichtung(en)
Adelaide and Meath Hospital
Goethe-Universität Frankfurt am Main
Monash University
Trinity College Dublin
Università degli Studi di Roma 'Tor Vergata'
University College Dublin (UCD)
University Hospital of Umeå / Norrlands universitetssjukhus (NUS)
University of Bath
University of Keele
University of Leeds
University of Manchester
University of Queensland


Zitierweisen

APA:
Bowes, J., Loehr, S., Budu-Aggrey, A., Uebe, S., Bruce, I.N., Feletar, M.,... Barton, A. (2015). PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus. Annals of the Rheumatic Diseases, 74(10), 1882-5. https://dx.doi.org/10.1136/annrheumdis-2014-207187

MLA:
Bowes, John, et al. "PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus." Annals of the Rheumatic Diseases 74.10 (2015): 1882-5.

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Zuletzt aktualisiert 2018-05-10 um 07:25