International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors

Hamann J, Aust G, Arac D, Engel F, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Proemel S, Schoeneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schoeith HB (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 67

Pages Range: 338-67

Journal Issue: 2

DOI: 10.1124/pr.114.009647

Abstract

The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Authors with CRIS profile

Involved external institutions

Uppsala University Sweden (SE) Julius-Maximilians-Universität Würzburg Germany (DE) University of Rochester (UR) United States (USA) (US) The European Bioinformatics Institute (EBI) United Kingdom (GB) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE) Stanford University United States (USA) (US) University of Kent United Kingdom (GB) University of Leeds United Kingdom (GB) Boston Children's Hospital United States (USA) (US) University of Copenhagen Denmark (DK) Universität Leipzig Germany (DE) Leiden University Netherlands (NL) Washington University United States (USA) (US) Chang Gung University (CGU) / 長庚大學 Taiwan (TW) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Emory University United States (USA) (US) King’s College London United Kingdom (GB) University of Chicago United States (USA) (US) University of Amsterdam Netherlands (NL)

How to cite

APA:

Hamann, J., Aust, G., Arac, D., Engel, F., Formstone, C., Fredriksson, R.,... Schoeith, H.B. (2015). International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacological Reviews, 67(2), 338-67. https://dx.doi.org/10.1124/pr.114.009647

MLA:

Hamann, Joerg, et al. "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors." Pharmacological Reviews 67.2 (2015): 338-67.

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