Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice
Pasquevich KA, Bieber K, Guenter M, Grauer M, Poetz O, Schleicher U, Biedermann T, Beer-Hammer S, Buehring HJ, Rammensee HG, Zender L, Autenrieth IB, Lengerke C, Autenrieth SE (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 45
Pages Range: 2821-33
Journal Issue: 10
Abstract
DCs are professional APCs playing a crucial role in the initiation of T-cell responses to combat infection. However, systemic bacterial infection with various pathogens leads to DC-depletion in humans and mice. The mechanisms of pathogen-induced DC-depletion remain poorly understood. Previously, we showed that mice infected with Yersinia enterocolitica (Ye) had impaired de novo DC-development, one reason for DC-depletion. Here, we extend these studies to gain insight into the molecular mechanisms of DC-depletion and the impact of different bacteria on DC-development. We show that the number of bone marrow (BM) hematopoietic progenitors committed to the DC lineage is reduced following systemic infection with different Gram-positive and Gram-negative bacteria. This is associated with a TLR4- and IFN-?-signaling dependent increase of committed monocyte progenitors in the BM and mature monocytes in the spleen upon Ye-infection. Adoptive transfer experiments revealed that infection-induced monopoiesis occurs at the expense of DC-development. Our data provide evidence for a general response of hematopoietic progenitors upon systemic bacterial infections to enhance monocyte production, thereby increasing the availability of innate immune cells for pathogen control, whereas impaired DC-development leads to DC-depletion, possibly driving transient immunosuppression in bacterial sepsis.
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Germany (DE)How to cite
APA:
Pasquevich, K.A., Bieber, K., Guenter, M., Grauer, M., Poetz, O., Schleicher, U.,... Autenrieth, S.E. (2015). Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice. European Journal of Immunology, 45(10), 2821-33. https://dx.doi.org/10.1002/eji.201545530
MLA:
Pasquevich, Karina A., et al. "Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice." European Journal of Immunology 45.10 (2015): 2821-33.
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