Common germline polymorphisms associated with breast cancer-specific survival

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Pirie A, Guo Q, Kraft P, Canisius S, Eccles DM, Rahman N, Nevanlinna H, Chen C, Khan S, Tyrer J, Bolla MK, Wang Q, Dennis J, Michailidou K, Lush M, Dunning AM, Shah M, Czene K, Darabi H, Eriksson M, Lambrechts D, Weltens C, Leunen K, Van Ongeval C, Nordestgaard BG, Nielsen SF, Flyger H, Rudolph A, Seibold P, Flesch-Janys D, Blomqvist C, Aittomaki K, Fagerholm R, Muranen TA, Olsen JE, Hallberg E, Vachon C, Knight JA, Glendon G, Mulligan AM, Broeks A, Cornelissen S, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Hopper JL, Tsimiklis H, Apicella C, Southey MC, Cross SS, Reed MWR, Giles GG, Milne RL, Mclean C, Winqvist R, Pylkas K, Jukkola-Vuorinen A, Grip M, Hooning MJ, Hollestelle A, Martens JWM, Van Den Ouweland AMW, Marme F, Schneeweiss A, Yang R, Burwinkel B, Figueroa J, Chanock SJ, Lissowska J, Sawyer EJ, Tomlinson I, Kerin MJ, Miller N, Brenner H, Butterbach K, Holleczek B, Kataja V, Kosma VM, Hartikainen JM, Li J, Brand JS, Humphreys K, Devilee P, Tollenaar RAEM, Seynaeve C, Radice P, Peterlongo P, Manoukian S, Ficarazzi F, Beckmann M, Hein A, Ekici AB, Balleine R, Phillips KA, Benitez J, Zamora MP, Perez JIA, Menendez P, Jakubowska A, Lubinski J, Gronwald J, Durda K, Hamann U, Kabisch M, Ulmer HU, Ruediger T, Margolin S, Kristensen V, Nord S, Evans DG, Abraham J, Earl H, Poole CJ, Hiller L, Dunn JA, Bowden S, Yang R, Campa D, Diver WR, Gapstur SM, Gaudet MM, Hankinson S, Hoover RN, Husing A, Kaaks R, Machiela MJ, Willett W, Barrdahl M, Canzian F, Chin SF, Caldas C, Hunter DJ, Lindstrom S, Garcia-Closas M, Couch FJ, Chenevix-Trench G, Mannermaa A, Andrulis IL, Hall P, Chang-Claude J, Easton DF, Bojesen SE, Cox A, Fasching P, Pharoah PDP, Schmidt MK
Zeitschrift: Breast Cancer Research
Jahr der Veröffentlichung: 2015
Band: 17
Seitenbereich: 58
ISSN: 1465-542X


Abstract


Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium.A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect.Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease.Although no variants reached genome-wide significance (P <5 x 10(-8)), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe
Hein, Alexander PD Dr.
Frauenklinik


Einrichtungen weiterer Autorinnen und Autoren

American Cancer Society
Antoni van Leeuwenhoek
Cambridge University Hospital
Cancer Council Victoria
Copenhagen University Hospital
Deutsches Krebsforschungszentrum (DKFZ)
Erasmus University Medical Center
Erasmus University Medical Center (MC)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Fondazione IRCCS: Istituto Nazionale dei Tumori
Harvard University
Helsingin yliopisto / University of Helsinki
Herlev Hospital
Hospital Monte Naranco
Hospital Universitario La Paz
IFOM - FIRC Institute of Molecular Oncology
Karolinska Institute
King’s College London
Klinikum Mittelbaden Baden-Baden Balg
Krebsregister Saarland / Saarland Cancer Registry
Kuopio University Hospital / Pohjois-Savon sairaanhoitopiiri
Leiden University
Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie
Mayo Clinic
Mount Sinai Hospital (MSH)
National Cancer Institute (NCI)
Oulun Yliopisto / University of Oulo
Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU)
QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research)
Ruprecht-Karls-Universität Heidelberg
Spanish National Cancer Research Centre / Centro Nacional de Investigaciones Oncológicas (CNIO)
Städtisches Klinikum Karlsruhe
The University of Melbourne
Universitätsklinikum Hamburg-Eppendorf (UKE)
University College London (UCL)
University Hospital Galway
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
University of Birmingham
University of Cambridge
University of Eastern Finland
University of Hawaii (U.H.)
University of Manchester
University of Oslo
University of Oxford
University of Sheffield
University of Southampton
University of Southern California (USC)
University of Sydney
University of Toronto
University of Warwick


Zitierweisen

APA:
Pirie, A., Guo, Q., Kraft, P., Canisius, S., Eccles, D.M., Rahman, N.,... Schmidt, M.K. (2015). Common germline polymorphisms associated with breast cancer-specific survival. Breast Cancer Research, 17, 58. https://dx.doi.org/10.1186/s13058-015-0570-7

MLA:
Pirie, Ailith, et al. "Common germline polymorphisms associated with breast cancer-specific survival." Breast Cancer Research 17 (2015): 58.

BibTeX: 

Zuletzt aktualisiert 2019-21-07 um 07:50