Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass

Journal article
(Original article)

Publication Details

Author(s): Esteban-Tejeda L, Zheng K, Prado C, Cabal B, Torrecillas R, Boccaccini AR, Moya JS
Journal: Journal of Non-Crystalline Solids
Publisher: Elsevier
Publication year: 2016
Volume: 432
Journal issue: Part A
Pages range: 73-80
ISSN: 0022-3093


This paper reports the fabrication, microstructural characterization, mechanical properties and antimicrobial activity of scaffolds obtained from a soda-lime glass powder constituted by micro-spheres belonging to the SiO-NaO-AlO-CaO - BO system. Scaffolds with a porosity > 90% were fabricated using the foam replication method in the temperature range of 750-850 °C. The highest compressive strength value (0.2 MPa) was obtained for the scaffolds sintered at 850 °C. The observed mechanical properties were rationalized considering the scaffold singular microstructure of the struts constituted by a dense packing of microspheres ranging from 4 to 30 μm interlocked by nepheline needle-like crystals. The antimicrobial test was performed against three different microorganisms: Escherichia coli, Staphylococcus aureus and Candida krusei (yeast). A 45S5 Bioglass® scaffold was also tested for comparison. A window glass scaffold was used as control. In all cases a safe disinfection was obtained (reduction > 99.9% = log of reduction > 3). The antimicrobial activity was found to be similar to that of 45S5 Bioglass® based scaffolds. However, the soda-lime scaffold sintered at 850 °C exhibited a higher antimicrobial activity (log of reduction > 5 = reduction > 99.999%) against C. krusei, which is a microorganism resistant to multiples biocides, than the Bioglass® scaffold (log of reduction < 2 = reduction > 99.0%).

FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Zheng, Kai Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

External institutions with authors

Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC)
Universidad de Oviedo

How to cite

Esteban-Tejeda, L., Zheng, K., Prado, C., Cabal, B., Torrecillas, R., Boccaccini, A.R., & Moya, J.S. (2016). Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass. Journal of Non-Crystalline Solids, 432(Part A), 73-80.

Esteban-Tejeda, Leticia, et al. "Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass." Journal of Non-Crystalline Solids 432.Part A (2016): 73-80.


Last updated on 2019-21-08 at 14:51