Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass

Esteban-Tejeda L, Zheng K, Prado C, Cabal B, Torrecillas R, Boccaccini AR, Moya JS (2016)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2016

Journal

Journal of Non-Crystalline Solids Elsevier

Publisher: Elsevier

Book Volume: 432

Pages Range: 73-80

Journal Issue: Part A

DOI: 10.1016/j.jnoncrysol.2015.05.040

Abstract

This paper reports the fabrication, microstructural characterization, mechanical properties and antimicrobial activity of scaffolds obtained from a soda-lime glass powder constituted by micro-spheres belonging to the SiO-NaO-AlO-CaO - BO system. Scaffolds with a porosity > 90% were fabricated using the foam replication method in the temperature range of 750-850 °C. The highest compressive strength value (0.2 MPa) was obtained for the scaffolds sintered at 850 °C. The observed mechanical properties were rationalized considering the scaffold singular microstructure of the struts constituted by a dense packing of microspheres ranging from 4 to 30 μm interlocked by nepheline needle-like crystals. The antimicrobial test was performed against three different microorganisms: Escherichia coli, Staphylococcus aureus and Candida krusei (yeast). A 45S5 Bioglass® scaffold was also tested for comparison. A window glass scaffold was used as control. In all cases a safe disinfection was obtained (reduction > 99.9% = log of reduction > 3). The antimicrobial activity was found to be similar to that of 45S5 Bioglass® based scaffolds. However, the soda-lime scaffold sintered at 850 °C exhibited a higher antimicrobial activity (log of reduction > 5 = reduction > 99.999%) against C. krusei, which is a microorganism resistant to multiples biocides, than the Bioglass® scaffold (log of reduction < 2 = reduction > 99.0%).

Authors with CRIS profile

Kai Zheng Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC) ES Spain (ES) Universidad de Oviedo ES Spain (ES)

How to cite

APA:

Esteban-Tejeda, L., Zheng, K., Prado, C., Cabal, B., Torrecillas, R., Boccaccini, A.R., & Moya, J.S. (2016). Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass. Journal of Non-Crystalline Solids, 432(Part A), 73-80. https://dx.doi.org/10.1016/j.jnoncrysol.2015.05.040

MLA:

Esteban-Tejeda, Leticia, et al. "Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass." Journal of Non-Crystalline Solids 432.Part A (2016): 73-80.

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