Lehmann B, Biburger M, Brückner C, Ipsen Escobedo A, Gordan S, Lehmann C, Vöhringer D, Winkler T, Schaft N, Dudziak D, Sirbu H, Nimmerjahn F, Weber G (2017)
Publication Type: Journal article, Original article
Publication year: 2017
Publisher: Science Immunology
Book Volume: 2
Journal Issue: 7
URI: http://immunology.sciencemag.org/content/2/7/eaah6413
DOI: 10.1126/sciimmunol.aah6413
Despite recent advances in activating immune cells to target tumors, the presence of some immune cells, such as tumor-associated macrophages (TAMs) or tumor-associated neutrophils (TANs), may promote rather than inhibit tumor growth. However, it remains unclear how antibody-dependent tumor immunotherapies, such as cytotoxic or checkpoint control antibodies, affect different TAM or TAN populations, which abundantly express activating Fcγ receptors. In this study, we show that the tissue environment determines which cellular effector pathways are responsible for antibody-dependent tumor immunotherapy. Although TAMs derived from Ly6Chigh monocytes recruited by the CCL2-CCR2 axis were critical for tumor immunotherapy of skin tumors, the destruction of lung tumors was CCL2-independent and required the presence of colony-stimulating factor 2{\textendash}dependent tissue-resident macrophages. Our findings suggest that TAMs may have a dual role not only in promoting tumor growth in certain tissue environments on the one hand but also in contributing to tumor cell destruction during antibody-mediated immunotherapy on the other hand.
APA:
Lehmann, B., Biburger, M., Brückner, C., Ipsen Escobedo, A., Gordan, S., Lehmann, C.,... Weber, G. (2017). Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response. Science immunology, 2(7). https://dx.doi.org/10.1126/sciimmunol.aah6413
MLA:
Lehmann, Birgit, et al. "Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response." Science immunology 2.7 (2017).
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