Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification
Blümcke I, Aronica E, Becker A, Capper D, Coras R, Honavar M, Jacques TS, Kobow K, Miyata H, Muhlebner A, Pimentel J, Soylemezoglu F, Thom M (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 12
Pages Range: 732-740
Journal Issue: 12
DOI: 10.1038/nrneurol.2016.173
Abstract
Rapid developments in molecular genetic technology and research have swiftly advanced our understanding of neuro-oncology. As a consequence, the WHO invited their expert panels to revise the current classification system of brain tumours and to introduce, for the first time, a molecular genetic approach for selected tumour entities, thus setting a new gold standard in histopathology. The revised 5th edition of the 'blue book' was released in May 2016 and will have a major impact in stratifying diagnosis and treatment. However, low-grade neuroepithelial tumours that present with early-onset focal epilepsy and are mostly seen in children and young adults (previously designated as long-term epilepsy-associated neuroepithelial tumours, LEAT) lack such innovative clinicopathological and molecular genetic tools. The Neuropathology Task Force of the International League against Epilepsy will critically discuss this issue, and will offer perspectives on how to decipher and validate clinically meaningful LEAT entities using the current WHO approach that integrates clinicopathological and genetic classification systems.
Authors with CRIS profile
Involved external institutions
Academic Medical Centre / Academisch Medisch Centrum (AMC)
Netherlands (NL)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Unidade Local de Saúde de Matosinhos
Portugal (PT)
University College London (UCL)
United Kingdom (GB)
Akita Research Institute of Brain and Blood Vessels / 秋田県立脳血管研究センター
Japan (JP)
Centro Hospitalar Universitário Lisboa Norte (CHULN)
Portugal (PT)
Hacettepe University
Turkey (TR)
Netherlands (NL)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Unidade Local de Saúde de Matosinhos
Portugal (PT)
University College London (UCL)
United Kingdom (GB)
Akita Research Institute of Brain and Blood Vessels / 秋田県立脳血管研究センター
Japan (JP)
Centro Hospitalar Universitário Lisboa Norte (CHULN)
Portugal (PT)
Hacettepe University
Turkey (TR)
How to cite
APA:
Blümcke, I., Aronica, E., Becker, A., Capper, D., Coras, R., Honavar, M.,... Thom, M. (2016). Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification. Nature Reviews Neurology, 12(12), 732-740. https://dx.doi.org/10.1038/nrneurol.2016.173
MLA:
Blümcke, Ingmar, et al. "Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification." Nature Reviews Neurology 12.12 (2016): 732-740.
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