Principles of the prolactin/vasoinhibin axis

Journal article

Publication Details

Author(s): Triebel J, Bertsch T, Bollheimer C, Rios-Barrera D, Pearce CF, Huefner M, Martnez De La Escalera G, Clapp C
Journal: American Journal of Physiology-Regulatory Integrative and Comparative Physiology
Publication year: 2015
Volume: 309
Journal issue: 10
Pages range: R1193-203
ISSN: 0363-6119


The hormonal family of vasoinhibins, which derive from the anterior pituitary hormone prolactin, are known for their inhibiting effects on blood vessel growth, vasopermeability, and vasodilation. As pleiotropic hormones, vasoinhibins act in multiple target organs and tissues. The generation, secretion, and regulation of vasoinhibins are embedded into the organizational principle of an axis, which integrates the hypothalamus, the pituitary, and the target tissue microenvironment. This axis is designated as the prolactin/vasoinhibin axis. Disturbances of the prolactin/vasoinhibin axis are associated with the pathogenesis of retinal and cardiac diseases and with diseases occurring during pregnancy. New phylogenetical, physiological, and clinical implications are discussed.

FAU Authors / FAU Editors

Bollheimer, Cornelius Prof. Dr.
Professur für Innere Medizin - Geriatrie

External institutions with authors

Centura Health
European Molecular Biology Laboratory (EMBL)
MVZ Endokrinologikum
National Autonomous University of Mexico / Universidad Nacional Autónoma de México (UNAM)
Paracelsus Medizinische Privatuniversität

How to cite

Triebel, J., Bertsch, T., Bollheimer, C., Rios-Barrera, D., Pearce, C.F., Huefner, M.,... Clapp, C. (2015). Principles of the prolactin/vasoinhibin axis. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 309(10), R1193-203.

Triebel, Jakob, et al. "Principles of the prolactin/vasoinhibin axis." American Journal of Physiology-Regulatory Integrative and Comparative Physiology 309.10 (2015): R1193-203.


Last updated on 2018-05-10 at 07:22