Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.

Unterseher F, Hefele J, Giehl K, De Robertis E, Wedlich D, Schambony A (2004)

Publication Language: English

Publication Type: Journal article, Original article

Subtype: other

Publication year: 2004

Journal

EMBO Journal EMBO Press

Publisher: Nature Publishing Group

Book Volume: 23

Pages Range: 3259-3269

Journal Issue: 16

URI: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=15297873&retmode=ref&cmd=prlinks

DOI: 10.1038/sj.emboj.7600332

Abstract

Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC functions as a signalling molecule that coordinates cell polarity of the involuting mesoderm in mediolateral orientation and thus selectively promotes convergence in CE movements. XPAPC signals through the small GTPases Rho A and Rac 1 and c-jun N-terminal kinase (JNK). Loss of XPAPC function blocks Rho A-mediated JNK activation. Despite common downstream components, XPAPC and Wnt/PCP signalling are not redundant, and the activity of both, XPAPC and PCP signalling, is required to coordinate CE movements.

Authors with CRIS profile

Alexandra Schambony Lehrstuhl für Entwicklungsbiologie

Involved external institutions

Justus-Liebig-Universität Gießen DE Germany (DE) University of California Los Angeles (UCLA) US United States (USA) (US)

How to cite

APA:

Unterseher, F., Hefele, J., Giehl, K., De Robertis, E., Wedlich, D., & Schambony, A. (2004). Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK. EMBO Journal, 23(16), 3259-3269. https://dx.doi.org/10.1038/sj.emboj.7600332

MLA:

Unterseher, Frank, et al. "Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK." EMBO Journal 23.16 (2004): 3259-3269.

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