Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development.

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autor(en): Schille C, Heller J, Schambony A
Zeitschrift: Bmc Developmental Biology
Verlag: BMC Developmental Biology
Jahr der Veröffentlichung: 2016
Band: 16
Seitenbereich: 1
ISSN: 1471-213X


Abstract


BACKGROUND:Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. BMPs activate heteromeric receptor complexes consisting of type I and type II receptor-serine/threonine kinases. BMP receptors Ia and Ib, also known as ALK3 and ALK6 respectively, are the most common type I receptors that likely mediate most BMP signaling events. Since early expression patterns and functions in Xenopus laevis development have not been described, we have addressed these questions in the present study.RESULTS:Here we have analyzed the temporal and spatial expression patterns of ALK3 and ALK6; we have also carried out loss-of-function studies to define the function of these receptors in early Xenopus development. We detected both redundant and non-redundant roles of ALK3 and ALK6 in dorso-ventral patterning. From late gastrula stages onwards, their expression patterns diverged, which correlated with a specific, non-redundant requirement of ALK6 in post-gastrula neural crest cells. ALK6 was essential for induction of neural crest cell fate and further development of the neural crest and its derivatives.CONCLUSIONS:ALK3 and ALK6 both contribute to the gene regulatory network that regulates dorso-ventral patterning; they play partially overlapping and partially non-redundant roles in this process. ALK3 and ALK6 are independently required for the spatially restricted activation of BMP signaling and msx2 upregulation at the neural plate border, whereas in post-gastrula development ALK6 exerts a highly specific, conserved function in neural crest development.



FAU-Autoren / FAU-Herausgeber

Heller, Jens
Interdisziplinäres Zentrum für Klinische Forschung IZKF Prof.Dr.Kalden Medizinische Klinik 3
Schambony, Alexandra PD Dr.
Lehrstuhl für Entwicklungsbiologie
Schille, Carolin
Lehrstuhl für Entwicklungsbiologie


Zitierweisen

APA:
Schille, C., Heller, J., & Schambony, A. (2016). Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development. Bmc Developmental Biology, 16, 1. https://dx.doi.org/10.1186/s12861-016-0101-5

MLA:
Schille, Carolin, Jens Heller, and Alexandra Schambony. "Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development." Bmc Developmental Biology 16 (2016): 1.

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Zuletzt aktualisiert 2018-10-08 um 15:53