Generation of HNO and HSNO from nitrite by heme-iron-catalyzed metabolism with H2S

Miljkovic J, Kenkel I, Ivanovic-Burmazovic I, Filipovic M (2013)

Publication Type: Journal article, Original article

Publication year: 2013

Journal

Angewandte Chemie International Edition Wiley

Original Authors: Miljkovic J.L., Kenkel I., Ivanovic-Burmazovic I., Filipovic M.R.

Publisher: Wiley-VCH Verlag

Book Volume: 52

Pages Range: 12061-12064

Journal Issue: 46

DOI: 10.1002/anie.201305669

Abstract

Taking NO for an answer: A mechanistic study has shown that a heme-iron-catalyzed pathway (see scheme) could lead to the nitrite-/sulfide- induced formation of NO and HNO within mitochondria, and suggests that H S may be the elusive thiol responsible for the reduction of nitrite. This study offers an answer to the decades-old question on the role of nitrite in the treatment of HS poisoning. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Authors with CRIS profile

Jan Miljkovic Lehrstuhl für Bioanorganische Chemie Isabell Kenkel Lehrstuhl für Bioanorganische Chemie Ivana Ivanovic-Burmazovic Lehrstuhl für Bioanorganische Chemie Milos Filipovic Lehrstuhl für Bioanorganische Chemie

How to cite

APA:

Miljkovic, J., Kenkel, I., Ivanovic-Burmazovic, I., & Filipovic, M. (2013). Generation of HNO and HSNO from nitrite by heme-iron-catalyzed metabolism with H2S. Angewandte Chemie International Edition, 52(46), 12061-12064. https://doi.org/10.1002/anie.201305669

MLA:

Miljkovic, Jan, et al. "Generation of HNO and HSNO from nitrite by heme-iron-catalyzed metabolism with H2S." Angewandte Chemie International Edition 52.46 (2013): 12061-12064.

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