Ackermann J, Radtke D, Maurberger A, Winkler T, Nitschke L (2011)
Publication Status: Published
Publication Type: Journal article
Publication year: 2011
Publisher: NATURE PUBLISHING GROUP
Book Volume: 30
Pages Range: 1621-1633
Journal Issue: 8
Grb2 is a ubiquitously expressed adaptor protein, which activates Ras and MAP kinases in growth factor receptor signalling, while in B-cell receptor (BCR) signalling this role is controversial. In B cell lines it was shown that Grb2 can inhibit BCR-induced Ca2+ signalling. Nonetheless, the physiological role of Grb2 in primary B cells is still unknown. We generated a B-cell-specific Grb2-deficient mouse line, which had a severe reduction of mature follicular B cells in the periphery due to a differentiation block and decreased B-cell survival. Moreover, we found several changes in important signalling pathways: enhanced BCR-induced Ca2+ signalling, alterations in mitogen-activated protein kinase activation patterns and strongly impaired Akt activation, the latter pointing towards a defect in PI3K signalling. Interestingly, B-cell-specific Grb2-deficient mice showed impaired IgG and B-cell memory responses, and impaired germinal centre formation. Thus, Grb2-dependent signalling pathways are crucial for lymphocyte differentiation processes, as well as for control of secondary humoral immune responses. The EMBO Journal (2011) 30, 1621-1633. doi:10.1038/emboj.2011.74; Published online 22 March 2011 Subject Categories: signal transduction; immunology
APA:
Ackermann, J., Radtke, D., Maurberger, A., Winkler, T., & Nitschke, L. (2011). Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling. EMBO Journal, 30(8), 1621-1633. https://doi.org/10.1038/emboj.2011.74
MLA:
Ackermann, Jochen, et al. "Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling." EMBO Journal 30.8 (2011): 1621-1633.
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