Presence of L-kynurenine aminotransferase III in retinal ganglion cells and corpora amylacea in the human retina and optic nerve
Rejdak R, Rummelt C, Zrenner E, Grieb P, Rejdak K, Okuno E, Thaler S, Nowomiejska K, Kruse F, Turski W, Jünemann A (2011)
Publication Type: Journal article
Publication year: 2011
Journal
Book Volume: 49
Pages Range: 132-7
Issue: 2
Abstract
Corpora amylacea (CAm) are a hallmark of aging and neurodegeneration. The presence of kynurenine aminotransferases I and II (KAT I and II) in CAm in the human retina and optic nerve has been already shown. The present study aimed to examine kynurenine aminotransferase III (KAT III) immunoreactivity in CAm in the human retina and optic nerve.Polyclonal antibody against KAT III was used on sections of human eyes enucleated due to malignant uveal melanoma. PAS-stained sections of CAm were compared with KAT III stained ones.KAT III immunoreactivity was observed in CAm in the retina, prelaminar, laminar and retrolaminar region of the optic nerve with similar location to PAS-stained sections. The most intense staining was observed in the retrolaminar part of the optic nerve. KAT III immunoreactivity was also present in the cytoplasm of retinal ganglion cells.Expression of KAT III in CAm in the human retina and optic nerve indicates that this enzyme may be relevant in mechanisms of neurodegeneration leading to CAm formation.
Authors with CRIS profile
Involved external institutions
Polska Akademia Nauk (PAN) / Polish Academy of Sciences
Poland (PL)
Kyushu Nutrition Welfare University
Japan (JP)
Universitätsklinikum Tübingen
Germany (DE)
Medical University of Lublin / Uniwersytet Medyczny w Lublinie
Poland (PL)
Poland (PL)
Kyushu Nutrition Welfare University
Japan (JP)
Universitätsklinikum Tübingen
Germany (DE)
Medical University of Lublin / Uniwersytet Medyczny w Lublinie
Poland (PL)
How to cite
APA:
Rejdak, R., Rummelt, C., Zrenner, E., Grieb, P., Rejdak, K., Okuno, E.,... Jünemann, A. (2011). Presence of L-kynurenine aminotransferase III in retinal ganglion cells and corpora amylacea in the human retina and optic nerve. Folia Neuropathologica, 49, 132-7.
MLA:
Rejdak, Robert, et al. "Presence of L-kynurenine aminotransferase III in retinal ganglion cells and corpora amylacea in the human retina and optic nerve." Folia Neuropathologica 49 (2011): 132-7.
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