Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice
Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, Hanisch UK, Triebel J, Bollheimer C, Sieber C, Nau R (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 12
Pages Range: 208
DOI: 10.1186/s12974-014-0208-1
Abstract
Meningoencephalitis caused by Escherichia coli is associated with high rates of mortality and risk of neurological sequelae in newborns and infants and in older or immunocompromised adults. A high prevalence of neurological disorders has been observed in geriatric populations at risk of hypovitaminosis D.In vivo, we studied the effects of vitamin D3 on survival and the host's immune response in experimental bacterial meningoencephalitis in mice after intracerebral E. coli infection. To produce different systemic vitamin D3 concentrations, mice received a low, standard, or high dietary vitamin D3 supplementation. Bacterial titers in blood, spleen, and brain homogenates were determined. Leukocyte infiltration was assessed by histological scores, and tissue cytokine or chemokine concentrations were measured.Mice fed a diet with low vitamin D3 concentration died earlier than control animals after intracerebral infection. Vitamin D deficiency did not inhibit leukocyte recruitment into the subarachnoid space and did not lead to an increased density of bacteria in blood, spleen, or brain homogenates. The release of proinflammatory interleukin (IL)-6 was decreased and the release of anti-inflammatory IL-10 was increased in mice fed a diet with high vitamin D3 supplementation.Our observations suggest a detrimental role of vitamin D deficiency in bacterial central nervous system infections. Vitamin D may exert immune regulatory functions.
Authors with CRIS profile
Cornelius Bollheimer
Professur für Innere Medizin - Geriatrie
Cornel Sieber
Lehrstuhl für Innere Medizin (Geriatrie)
Involved external institutions
Universitätsklinikum Göttingen
Germany (DE)
Evangelisches Krankenhaus Göttingen-Weende
Germany (DE)
Paracelsus Medizinische Privatuniversität
Austria (AT)
Germany (DE)
Evangelisches Krankenhaus Göttingen-Weende
Germany (DE)
Paracelsus Medizinische Privatuniversität
Austria (AT)
How to cite
APA:
Djukic, M., Sostmann, N., Bertsch, T., Mecke, M., Nessler, S., Manig, A.,... Nau, R. (2015). Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. Journal of Neuroinflammation, 12, 208. https://dx.doi.org/10.1186/s12974-014-0208-1
MLA:
Djukic, Marija, et al. "Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice." Journal of Neuroinflammation 12 (2015): 208.
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