Palliative Treatment of Colorectal Cancer with Secondary Metastasis Resection in Germany - Impact of the Multidisciplinary Treatment Approach on Prognosis and Cost: The Northern Bavaria IVOPAK I Project

Journal article
(Medical case study)


Publication Details

Author(s): Wein A, Emmert M, Merkel S, Harich HD, Siebler J, Thiemann R, Lamberti C, Göttler B, Fries S, Kiani A, Schlag R, Grüner M, Steinbild S, Eberl S, Pohl-Dernick K, Dörje F, Horbach T, Schöffski O, Neurath MF, Hohenberger W
Journal: Oncology
Publisher: Karger
Publication year: 2015
Volume: 88
Journal issue: 2
Pages range: 103 - 121
ISSN: 0030-2414
eISSN: 1423-0232
Language: English


Abstract


Purpose



The aim of this study was to evaluate the quality of care and interdisciplinary cooperation in the palliative treatment of colorectal cancer (CRC), including the associated costs. 



Patients and Methods 



103 patients were enrolled from 13 institutions to reflect the existing clinical treatment reality and costs of palliative CRC treatment. We present the clinical outcome of the patients and compare the results obtained in the 3 centers with double-figure recruitment numbers (centers A, B, and C). 



Results 



First-line treatment with 5-fluorouracil monotherapy was applied in exceptional cases. The regular treatment method comprised either an irinotecan- (30%) or an oxaliplatin-based regimen (32%). Biological agents were added to the treatment of 33 patients (32%). The median overall survival (OS) of the total patient collective was 25 months. The OS differed significantly in 2 out of the 3 centers, ranging between 27 and 11 months. Secondary metastasis resections were performed in 26% of the total patient collective. The center with the most favorable outcome results also had the lowest costs for palliative treatment and care, including the lowest drug costs. 



Conclusion 



A combined chemotherapy treatment was the rule. Concerning biological agents, a significant lack of their application in first-line treatment and the quality of interdisciplinary cooperation have to be addressed.



FAU Authors / FAU Editors

Dörje, Frank Prof. Dr.
Lehrstuhl für Pharmazeutische Technologie
Emmert, Martin PD Dr.
Juniorprofessur für Versorgungsmanagement
Hohenberger, Werner Prof. Dr.
Lehrstuhl für Allgemein- und Viszeralchirurgie
Merkel, Susanne Prof. Dr.
Chirurgische Klinik
Neurath, Markus Prof. Dr.
Lehrstuhl für Innere Medizin I
Pohl-Dernick, Katharina
Lehrstuhl für Betriebswirtschaftslehre, insbesondere Gesundheitsmanagement
Schöffski, Oliver Prof. Dr.
Lehrstuhl für Betriebswirtschaftslehre, insbesondere Gesundheitsmanagement
Wein, Axel Prof. Dr.
Medizinische Fakultät


External institutions with authors

Gemeinschaftspraxis Hämatolgie / Onkologie Muhr am See
Hämatologie Gemeinschaftspraxis Forchheim
Klinikum Bayreuth
Krankenhaus Martha-Maria Nürnberg
Medizinisches Versorgungszentrum Klinikum Coburg
Onkologie Hof - Medizinisches Versorgungszentrum GmbH
Onkologische Gemeinschaftspraxis Weiden
Onkologische Gemeinschaftspraxis Würzburg
Onkologische Schwerpunktpraxis Bamberg
Stadtkrankenhaus Schwabach


How to cite

APA:
Wein, A., Emmert, M., Merkel, S., Harich, H.-D., Siebler, J., Thiemann, R.,... Hohenberger, W. (2015). Palliative Treatment of Colorectal Cancer with Secondary Metastasis Resection in Germany - Impact of the Multidisciplinary Treatment Approach on Prognosis and Cost: The Northern Bavaria IVOPAK I Project. Oncology, 88(2), 103 - 121. https://dx.doi.org/10.1159/000368246

MLA:
Wein, Axel, et al. "Palliative Treatment of Colorectal Cancer with Secondary Metastasis Resection in Germany - Impact of the Multidisciplinary Treatment Approach on Prognosis and Cost: The Northern Bavaria IVOPAK I Project." Oncology 88.2 (2015): 103 - 121.

BibTeX: 

Last updated on 2018-10-08 at 01:39