FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.

Nimmerjahn F, Lux A, Albert H, Woigk M, Lehmann C, Dudziak D, Smith P, Ravetch JV (2010)


Publication Status: Published

Publication Type: Journal article

Publication year: 2010

Journal

Book Volume: 107

Pages Range: 19396-401

Journal Issue: 45

DOI: 10.1073/pnas.1014515107

Abstract

Cellular Fcγ receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fcγ receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in FcγRIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating FcγRs. To study the role of individual activating FcγRs for IgG subclass activity, we generated an FcγRIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.

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APA:

Nimmerjahn, F., Lux, A., Albert, H., Woigk, M., Lehmann, C., Dudziak, D.,... Ravetch, J.V. (2010). FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo. Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19396-401. https://dx.doi.org/10.1073/pnas.1014515107

MLA:

Nimmerjahn, Falk, et al. "FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo." Proceedings of the National Academy of Sciences of the United States of America 107.45 (2010): 19396-401.

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