Efficient generation of a monoclonal antibody against the human C-type lectin receptor DCIR by targeting murine dendritic cells.

Heidkamp GF, Neubert K, Härtel E, Nimmerjahn F, Nussenzweig MC, Dudziak D (2010)

Publication Status: Published

Publication Type: Journal article

Publication year: 2010

Journal

Immunology letters

Book Volume: 132

Pages Range: 69-78

Journal Issue: 1-2

DOI: 10.1016/j.imlet.2010.06.002

Abstract

Dendritic cells (DCs) are very important for the generation of long lasting immune responses against pathogens or the induction of anti-tumor responses. Targeting antigen to dendritic cells via monoclonal antibodies specific for DC cell surface receptors such as DEC205 was shown to elicit potent cellular and humoral immune responses in vivo. Therefore, we investigated whether this novel strategy might also be useful for the generation of new monoclonal antibodies against molecules of choice. We show, that by targeting the extracellular domain of the human C-type lectin receptor ClecSF6/DCIR/LLIR (hDCIR) to DEC205 on DCs in vivo, we were able to generate highly specific monoclonal antibodies against hDCIR.

Authors with CRIS profile

Gordon Frederik Heidkamp Professur für Genetik Falk Nimmerjahn Lehrstuhl für Genetik Diana Dudziak Professur für die Biologie Dendritischer Zellen

Involved external institutions

Rockefeller University US United States (USA) (US)

How to cite

APA:

Heidkamp, G.F., Neubert, K., Härtel, E., Nimmerjahn, F., Nussenzweig, M.C., & Dudziak, D. (2010). Efficient generation of a monoclonal antibody against the human C-type lectin receptor DCIR by targeting murine dendritic cells. Immunology letters, 132(1-2), 69-78. https://doi.org/10.1016/j.imlet.2010.06.002

MLA:

Heidkamp, Gordon Frederik, et al. "Efficient generation of a monoclonal antibody against the human C-type lectin receptor DCIR by targeting murine dendritic cells." Immunology letters 132.1-2 (2010): 69-78.

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