Suppressing the Antibody Response with Siglec Ligands

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Details zur Publikation

Autorinnen und Autoren: Nitschke L
Zeitschrift: New England Journal of Medicine
Jahr der Veröffentlichung: 2013
Band: 369
Heftnummer: 14
Seitenbereich: 1373-1374
ISSN: 0028-4793


Production of antibodies to self-antigens is a risk factor for autoimmune disease. A potential strategy to suppress production of specific antibodies by B cells may involve stimulation of a class of repressor receptors, the sialic acid-binding immunoglobulin-like lectins. When stimulated by antigens, B cells produce antibodies a crucial response against pathogens and the basis of all successful vaccines. The dark side of this immune response is that it can be directed against self-antigens, potentially resulting in autoimmune disease. Autoreactive B cells are largely eliminated in the bone marrow, but some escape the bone marrow and are found in the periphery as polyreactive or autoreactive B cells. However, a second mechanism guards against autoimmune mayhem: inhibitory receptors expressed on the surface of B cells for example, the sialic acid-binding immunoglobulin-like lectins (Siglecs) prevent autoimmune reactions. Macauley ...

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Nitschke, Lars Prof. Dr.
Professur für Genetik


Nitschke, L. (2013). Suppressing the Antibody Response with Siglec Ligands. New England Journal of Medicine, 369(14), 1373-1374.

Nitschke, Lars. "Suppressing the Antibody Response with Siglec Ligands." New England Journal of Medicine 369.14 (2013): 1373-1374.


Zuletzt aktualisiert 2018-09-08 um 00:09