Nitschke L (2013)
Publication Status: Published
Publication Type: Journal article, Note
Publication year: 2013
Publisher: MASSACHUSETTS MEDICAL SOC
Book Volume: 369
Pages Range: 1373-1374
Journal Issue: 14
Production of antibodies to self-antigens is a risk factor for autoimmune disease. A potential strategy to suppress production of specific antibodies by B cells may involve stimulation of a class of repressor receptors, the sialic acid-binding immunoglobulin-like lectins. When stimulated by antigens, B cells produce antibodies a crucial response against pathogens and the basis of all successful vaccines. The dark side of this immune response is that it can be directed against self-antigens, potentially resulting in autoimmune disease. Autoreactive B cells are largely eliminated in the bone marrow, but some escape the bone marrow and are found in the periphery as polyreactive or autoreactive B cells. However, a second mechanism guards against autoimmune mayhem: inhibitory receptors expressed on the surface of B cells for example, the sialic acid-binding immunoglobulin-like lectins (Siglecs) prevent autoimmune reactions. Macauley ...
APA:
Nitschke, L. (2013). Suppressing the Antibody Response with Siglec Ligands. New England Journal of Medicine, 369(14), 1373-1374. https://dx.doi.org/10.1056/NEJMcibr1308953
MLA:
Nitschke, Lars. "Suppressing the Antibody Response with Siglec Ligands." New England Journal of Medicine 369.14 (2013): 1373-1374.
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