International consensus guidance for management of myasthenia gravis: Executive summary

Sanders DB, Wolfe GI, Benatar M, Evoli A, Gilhus NE, Illa I, Kuntz N, Massey JM, Melms A, Murai H, Nicolle M, Palace J, Richman DP, Verschuuren J, Narayanaswami P (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Neurology American Academy of Neurology (AAN)

Book Volume: 87

Pages Range: 419-25

Journal Issue: 4

DOI: 10.1212/WNL.0000000000002790

Abstract

To develop formal consensus-based guidance for the management of myasthenia gravis (MG).In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was convened. The RAND/UCLA appropriateness methodology was used to develop consensus guidance statements. Definitions were developed for goals of treatment, minimal manifestations, remission, ocular MG, impending crisis, crisis, and refractory MG. An in-person panel meeting then determined 7 treatment topics to be addressed. Initial guidance statements were developed from literature summaries. Three rounds of anonymous e-mail votes were used to attain consensus on guidance statements modified on the basis of panel input.Guidance statements were developed for symptomatic and immunosuppressive treatments, IV immunoglobulin and plasma exchange, management of impending and manifest myasthenic crisis, thymectomy, juvenile MG, MG associated with antibodies to muscle-specific tyrosine kinase, and MG in pregnancy.This is an international formal consensus of MG experts intended to be a guide for clinicians caring for patients with MG worldwide.

Involved external institutions

Duke University US United States (USA) (US) University at Buffalo. State University of New York US United States (USA) (US) University of Miami US United States (USA) (US) Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore IT Italy (IT) University of Bergen / Universitetet i Bergen NO Norway (NO) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona ES Spain (ES) Northwestern University US United States (USA) (US) Kyushu University / 九州大学 JP Japan (JP) Western University CA Canada (CA) Oxford University Hospitals NHS Foundation Trust GB United Kingdom (GB) University of California Davis (UCDAVIS) US United States (USA) (US) Leiden University NL Netherlands (NL) Harvard University US United States (USA) (US)

How to cite

APA:

Sanders, D.B., Wolfe, G.I., Benatar, M., Evoli, A., Gilhus, N.E., Illa, I.,... Narayanaswami, P. (2016). International consensus guidance for management of myasthenia gravis: Executive summary. Neurology, 87(4), 419-25. https://dx.doi.org/10.1212/WNL.0000000000002790

MLA:

Sanders, Donald B., et al. "International consensus guidance for management of myasthenia gravis: Executive summary." Neurology 87.4 (2016): 419-25.

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