Human leukocyte antigen-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies

Kremer A, Van Der Meijden ED, Honders MW, Pont MJ, Goeman JJ, Falkenburg JHF, Griffioen M (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Biology of Blood and Marrow Transplantation Elsevier

Book Volume: 20

Pages Range: 742-7

Journal Issue: 5

DOI: 10.1016/j.bbmt.2014.02.005

Abstract

Hematological malignancies often express surface HLA class II, making them attractive targets for CD4+ T cell therapy. We previously demonstrated that HLA class II ligands can be divided into DM-resistant and DM-sensitive antigens. In contrast to presentation of DM-resistant antigens, presentation of DM-sensitive antigens is suppressed by HLA-DM but can be rescued by HLA-DO. We also showed that HLA-DO expression remains low in nonhematopoietic cells under inflammatory conditions, suggesting that DM-sensitive antigens may be ideal T cell targets with a low risk for graft-versus-host disease. Here, we demonstrated that B cell malignancies often express HLA-DO and that levels are in particular high in chronic lymphocytic leukemia. Moreover, we showed that surface presentation of DM-sensitive antigens is regulated by HLA-DO, and that DM-sensitive antigens are relevant T cell targets for B cell malignancies and, especially, chronic lymphocytic leukemia. These data open the perspective to target HLA class II ligands with specific processing and presentation behavior for CD4+ T cell therapy of hematological malignancies.

Authors with CRIS profile

Anita Kremer Department of Medicine 5 – Haematology and Oncology

Involved external institutions

Leiden University NL Netherlands (NL)

How to cite

APA:

Kremer, A., Van Der Meijden, E.D., Honders, M.W., Pont, M.J., Goeman, J.J., Falkenburg, J.H.F., & Griffioen, M. (2014). Human leukocyte antigen-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. Biology of Blood and Marrow Transplantation, 20(5), 742-7. https://doi.org/10.1016/j.bbmt.2014.02.005

MLA:

Kremer, Anita, et al. "Human leukocyte antigen-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies." Biology of Blood and Marrow Transplantation 20.5 (2014): 742-7.

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