Hxt1, a monosaccharide transporter and sensor required for virulence of the maize pathogen Ustilago maydis

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Schuler D, Wahl R, Wippel K, Vranes M, Münsterkötter M, Sauer N, Kämper J
Zeitschrift: New Phytologist
Verlag: WILEY-BLACKWELL
Jahr der Veröffentlichung: 2015
Band: 206
Heftnummer: 3
Seitenbereich: 1086-1100
ISSN: 0028-646X
Sprache: Englisch


Abstract


The smut Ustilago maydis, a ubiquitous pest of corn, is highly adapted to its host to parasitize on its organic carbon sources. We have identified a hexose transporter, Hxt1, as important for fungal development during both the saprophytic and the pathogenic stage of the fungus. Hxt1 was characterized as a high-affinity transporter for glucose, fructose, and mannose; hxt1 strains show significantly reduced growth on these substrates, setting Hxt1 as the main hexose transporter during saprophytic growth. After plant infection, hxt1 strains show decreased symptom development. However, expression of a Hxt1 protein with a mutation leading to constitutively active signaling in the yeast glucose sensors Snf3p and Rgt2p results in completely apathogenic strains. Fungal development is stalled immediately after plant penetration, implying a dual function of Hxt1 as transporter and sensor. As glucose sensors are only known for yeasts, transceptor' as Hxt1 may constitute a general mechanism for sensing of glucose in fungi. In U.maydis, Hxt1 links a nutrient-dependent environmental signal to the developmental program during pathogenic development.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Sauer, Norbert Prof. Dr.
Lehrstuhl für Molekulare Pflanzenphysiologie


Einrichtungen weiterer Autorinnen und Autoren

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU)
Karlsruhe Institute of Technology (KIT)


Zitierweisen

APA:
Schuler, D., Wahl, R., Wippel, K., Vranes, M., Münsterkötter, M., Sauer, N., & Kämper, J. (2015). Hxt1, a monosaccharide transporter and sensor required for virulence of the maize pathogen Ustilago maydis. New Phytologist, 206(3), 1086-1100. https://dx.doi.org/10.1111/nph.13314

MLA:
Schuler, David, et al. "Hxt1, a monosaccharide transporter and sensor required for virulence of the maize pathogen Ustilago maydis." New Phytologist 206.3 (2015): 1086-1100.

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Zuletzt aktualisiert 2018-10-08 um 13:39