Characterizations of drug carrying magnetic nanoparticles for tumor therapy: Biological outcome and first immunological aspects

Dürr S, Tietze R, Lyer S, Janko C, Schreiber E, Mann J, Turcu R, Gitter K, Odenbach S, Vasylyev S, Herrmann M, Peukert W, Alexiou C (2013)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2013

Journal

Magnetohydrodynamics

Book Volume: 49

Pages Range: 552-559

Journal Issue: 3/4

URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84890253895&origin=inward

Abstract

Nanosized magnetic drug carriers offer a splendid prospect for directed drug application. The increased drug concentration in cancer tissue reached for this kind of application enables therapeutic effects on tumors that cannot be achieved using conventional chemotherapeutic treatment. Characterizing the drug targeting system and its behavior in vitro is necessary for understanding the biological outcome. In our studies, IRspectroscopy shows covalent binding of the biocompatible fatty acid layer. Although binding of mitoxantrone (MTO) to particles is hardly defined, considerable amounts of drug can be carried by nanoparticles. Furthermore, the nanosized drug carrier complex has to be investigated due to its biological outcome. Real-time cell analysis is useful to observe the therapeutic particles concerning their outcome in cell culture time-resolved up to several days. First experiments in concordance to a conventional assay show that the effectivity of nanoparticle bound MTO in cell culture is higher than treatment with pure MTO. A preliminary study demonstrates that the burden of the immune system is reduced by Magnetic Drug Targeting (MDT) vs. conventional chemotherapy. For a better understanding of MDT for cancer treatment, further studies have to be done to explain especially the binding behavior of superparamagnetic iron oxide nanoparticles to the respective chemotherapeutic agent.

Authors with CRIS profile

Rainer Tietze Department of Otorhinolaryngology – Head and Neck Surgery Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery Christina Janko Department of Otorhinolaryngology – Head and Neck Surgery Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology Wolfgang Peukert Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Christoph Alexiou Professur für Nanomedizin

Involved external institutions

National Institute for Research and Development of Isotopic and Molecular Technologies / Institutul Naţional de Cercetare Dezvoltare pentru Tehnologii Izotopice şi Moleculare (INCDTIM) RO Romania (RO) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Dürr, S., Tietze, R., Lyer, S., Janko, C., Schreiber, E., Mann, J.,... Alexiou, C. (2013). Characterizations of drug carrying magnetic nanoparticles for tumor therapy: Biological outcome and first immunological aspects. Magnetohydrodynamics, 49(3/4), 552-559.

MLA:

Dürr, Stephan, et al. "Characterizations of drug carrying magnetic nanoparticles for tumor therapy: Biological outcome and first immunological aspects." Magnetohydrodynamics 49.3/4 (2013): 552-559.

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