Demyelinating disease and anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies: a case report

Journal article


Publication Details

Author(s): Waschbisch A, Kallmünzer B, Schwab S, Gölitz P, Vincent A, Lee DH, Linker R
Journal: BMC Research Notes
Publication year: 2014
Volume: 7
Pages range: 948
ISSN: 1756-0500


Abstract


Anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies directed against the GluN1 subunit are considered highly specific for anti-N-methyl-D-aspartate receptor encephalitis, a severe clinical syndrome characterized by seizures, psychiatric symptoms, orofacial dyskinesia and autonomic dysfunction.Here we report a 33 year old Caucasian male patient with clinically definite multiple sclerosis who was found to be positive for anti-N-methyl-D-aspartate receptor antibodies. Rituximab therapy was initiated. On the 18 months follow-up visit the patient was found to be clinically stable, without typical signs of anti-N-methyl-D-aspartate receptor encephalitis.Our findings add to the growing evidence for a possible association between anti-N-methyl-D-aspartate receptor encephalitis and demyelinating diseases.



FAU Authors / FAU Editors

Gölitz, Philipp PD Dr.
Medizinische Fakultät
Kallmünzer, Bernd PD Dr.
Medizinische Fakultät
Linker, Ralf PD Dr.
Neurologische Klinik
Schwab, Stefan Prof. Dr.
Lehrstuhl für Neurologie
Waschbisch, Anne PD Dr.
Neurologische Klinik


External institutions with authors

University of Oxford


How to cite

APA:
Waschbisch, A., Kallmünzer, B., Schwab, S., Gölitz, P., Vincent, A., Lee, D.H., & Linker, R. (2014). Demyelinating disease and anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies: a case report. BMC Research Notes, 7, 948. https://dx.doi.org/10.1186/1756-0500-7-948

MLA:
Waschbisch, Anne, et al. "Demyelinating disease and anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies: a case report." BMC Research Notes 7 (2014): 948.

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Last updated on 2019-24-06 at 08:48