Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy

Schneider M, Engel A, Fasching P, Haeberle L, Binder EB, Voigt F, Grimm J, Faschingbauer F, Eichler A, Dammer U, Rebhan D, Amann M, Raabe E, Goecke TW, Quast C, Beckmann M, Kornhuber J, Seifert A, Burghaus S (2014)

Publication Type: Journal article

Publication year: 2014

Journal

BioMed Research International Hindawi

Book Volume: 2014

Pages Range: 469278

DOI: 10.1155/2014/469278

Abstract

The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes of the stress hormone signaling pathway, specifically FKBP5, NR3C1, and CRHR1, are associated with depressive symptoms during and after pregnancy.The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for the assessment of maternal and fetal health including the assessment of depressiveness. The German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) was completed at three time points in this prospective cohort study. Visit 1 was at study entry in the third trimester of the pregnancy, visit 2 was shortly after birth, and visit 3 was 6-8 months after birth. Germline DNA was collected from 361 pregnant women. Nine SNPs in the above mentioned genes were genotyped. After construction of haplotypes for each gene, a multifactorial linear mixed model was performed to analyse the depression values over time.EPDS values were within expected ranges and comparable to previously published studies. Neither did the depression scores differ for comparisons among haplotypes at fixed time points nor did the change over time differ among haplotypes for the examined genes. No haplotype showed significant associations with depressive symptoms severity during pregnancy or the postpartum period.The analysed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show an association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.

Authors with CRIS profile

Anne Engel Professur für Translationale Frauenheilkunde und Geburtshilfe Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe Anna Eichler Department of Child and Adolescent Mental Health Dirk Rebhan Medizinische Fakultät Manuela Amann Professur für Translationale Frauenheilkunde und Geburtshilfe Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Stefanie Burghaus Department of Obstetrics and Gynaecology

Involved external institutions

Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE) Max-Planck-Institut für Psychiatrie (Deutsche Forschungsanstalt für Psychiatrie) DE Germany (DE)

How to cite

APA:

Schneider, M., Engel, A., Fasching, P., Haeberle, L., Binder, E.B., Voigt, F.,... Burghaus, S. (2014). Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy. BioMed Research International, 2014, 469278. https://doi.org/10.1155/2014/469278

MLA:

Schneider, Michael, et al. "Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy." BioMed Research International 2014 (2014): 469278.

BibTeX: Download