Role of Tyk-2 in Th9 and Th17 cells in allergic asthma
Ubel C, Graser A, Koch S, Rieker RJ, Lehr HA, Mueller M, Finotto S (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 4
Pages Range: 5865
DOI: 10.1038/srep05865
Abstract
In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and IL-13. We also observed increased Th9 cells expressing IL-9 and IL-10 as well as T helper cells expressing IL-6, IL-10 and IL-21 with a defect in IL-17A and IL-17F production. This T helper phenotype was accompanied by increased SOCS3 in the lung of Tyk-2 deficient asthmatic mice. Finally, in vivo treatment with rIL-17A inhibited local CD4(+)CD25(+)Foxp3(+) T regulatory cells as well as Th2 cytokines without affecting IL-9 in the lung. These results suggest a role of Tyk-2 in different subsets of T helper cells mediated by SOCS3 regulation that is relevant for the treatment of asthma, cancer and autoimmune diseases.
Authors with CRIS profile
Anna Graser
Department of Molecular Pneumology
Susetta Neurath-Finotto
Department of Molecular Pneumology
Involved external institutions
Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV)
Switzerland (CH)
Veterinärmedizinische Universität Wien (Vetmeduni Vienna) / University of Veterinary Medicine, Vienna
Austria (AT)
Switzerland (CH)
Veterinärmedizinische Universität Wien (Vetmeduni Vienna) / University of Veterinary Medicine, Vienna
Austria (AT)
How to cite
APA:
Ubel, C., Graser, A., Koch, S., Rieker, R.J., Lehr, H.A., Mueller, M., & Finotto, S. (2014). Role of Tyk-2 in Th9 and Th17 cells in allergic asthma. Scientific Reports, 4, 5865. https://doi.org/10.1038/srep05865
MLA:
Ubel, Caroline, et al. "Role of Tyk-2 in Th9 and Th17 cells in allergic asthma." Scientific Reports 4 (2014): 5865.
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