Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment

Wolfsgruber S, Wagner M, Schmidtke K, Froelich L, Kurz A, Schulz S, Hampel H, Heuser I, Peters O, Reischies FM, Jahn H, Luckhaus C, Huell M, Gertz HJ, Schroeder J, Pantel J, Rienhoff O, Ruether E, Henn F, Wiltfang J, Maier W, Kornhuber J, Jessen F (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Book Volume: 9

Pages Range: e100812

Journal Issue: 7

DOI: 10.1371/journal.pone.0100812

Abstract

Concerns about worsening memory ("memory concerns"; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI).We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n = 305) vs. absence (n = 112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models.Risk of incident AD was increased by MC (HR = 2.55, 95%CI: 1.33-4.89), lower memory performance (HR = 0.63, 95%CI: 0.56-0.71) and ApoE4-genotype (HR = 1.89, 95%CI: 1.18-3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment.Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI.

Authors with CRIS profile

Involved external institutions

Ludwig-Maximilians-Universität (LMU) Germany (DE) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Germany (DE) Technische Universität München (TUM) Germany (DE) Zentralinstitut für Seelische Gesundheit Germany (DE) Ortenau Klinikum Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Universität Duisburg-Essen (UDE) Germany (DE) Brookhaven National Laboratory United States (USA) (US) Georg-August-Universität Göttingen Germany (DE) Goethe-Universität Frankfurt am Main Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Universität Leipzig Germany (DE) Albert-Ludwigs-Universität Freiburg Germany (DE) Heinrich-Heine-Universität Düsseldorf Germany (DE) Universität Hamburg (UHH) Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE)

How to cite

APA:

Wolfsgruber, S., Wagner, M., Schmidtke, K., Froelich, L., Kurz, A., Schulz, S.,... Jessen, F. (2014). Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment. PLoS ONE, 9(7), e100812. https://doi.org/10.1371/journal.pone.0100812

MLA:

Wolfsgruber, Steffen, et al. "Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment." PLoS ONE 9.7 (2014): e100812.

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