FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Agarwal D, Pineda S, Michailidou K, Herranz J, Pita G, Moreno LT, Alonso MR, Dennis J, Wang Q, Bolla MK, Meyer KB, Menendez-Rodriguez P, Hardisson D, Mendiola M, Gonzalez-Neira A, Lindblom A, Margolin S, Swerdlow A, Ashworth A, Orr N, Jones M, Matsuo K, Ito H, Iwata H, Kondo N, Hartman M, Hui M, Lim WY, Iau PTC, Sawyer E, Tomlinson I, Kerin M, Miller N, Kang D, Choi JY, Park SK, Noh DY, Hopper JL, Schmidt DF, Makalic E, Southey MC, Teo SH, Yip CH, Sivanandan K, Tay WT, Brauch H, Bruening T, Hamann U, Dunning AM, Shah M, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Schmidt MK, Broeks A, Rosenberg EH, Van'T Veer LJ, Fasching P, Renner S, Ekici AB, Beckmann M, Shen CY, Hsiung CN, Yu JC, Hou MF, Blot W, Cai Q, Wu AH, Tseng CC, Van Den Berg D, Stram DO, Cox A, Brock IW, Reed MWR, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Zheng W, Deming-Halverson S, Shrubsole MJ, Long J, Shu XO, Lu W, Gao YT, Zhang B, Radice P, Peterlongo P, Manoukian S, Mariette F, Sangrajrang S, Mckay J, Couch FJ, Toland AE, Yannoukakos D, Fletcher O, Johnson N, Dos Santos Silva I, Peto J, Marme F, Burwinkel B, Guenel P, Truong T, Sanchez M, Mulot C, Bojesen SE, Nordestgaard BG, Flyer H, Brenner H, Dieffenbach AK, Arndt V, Stegmaier C, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Chang-Claude J, Rudolph A, Seibold P, Flesch-Janys D, Wang X, Olson JE, Vachon C, Purrington K, Giles GG, Severi G, Baglietto L, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Simard J, Dumont M, Goldberg MS, Labreche F, Winqvist R, Pylkaes K, Jukkola-Vuorinen A, Grip M, Devilee P, Tollenaar RAEM, Seynaeve C, Garcia-Closas M, Chanock SJ, Lissowska J, Figueroa JD, Czene K, Eriksson M, Humphreys K, Darabi H, Hooning MJ, Kriege M, Collee JM, Tilanus-Linthorst M, Li J, Jakubowska A, Lubinski J, Jaworska-Bieniek K, Durda K, Nevanlinna H, Muranen TA, Aittomaeki K, Blomqvist C, Bogdanova N, Doerk T, Hall P, Chenevix-Trench G, Easton DF, Pharoah PDP, Arias-Perez JI, Zamora P, Benitez J, Milne RL (2014)


Publication Type: Journal article

Publication year: 2014

Journal

Book Volume: 110

Pages Range: 1088-100

Journal Issue: 4

DOI: 10.1038/bjc.2013.769

Abstract

Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

Authors with CRIS profile

Involved external institutions

Spanish National Cancer Research Centre / Centro Nacional de Investigaciones Oncológicas (CNIO) ES Spain (ES) Karolinska Institute SE Sweden (SE) Hospital Universitario La Paz ES Spain (ES) Universidad Autónoma de Madrid (UAM) ES Spain (ES) University of Cambridge GB United Kingdom (GB) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) AU Australia (AU) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Helsingin yliopisto / University of Helsinki FI Finland (FI) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) PL Poland (PL) Genome Institute of Singapore SG Singapore (SG) Erasmus University Rotterdam (EUR) / Erasmus Universiteit Rotterdam NL Netherlands (NL) Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) London School of Hygiene and Tropical Medicine GB United Kingdom (GB) National Centre for Scientific Research (NCSR) "Demokritos" GR Greece (GR) Ohio State University US United States (USA) (US) Mayo Clinic US United States (USA) (US) International Agency for Research on Cancer (IARC) FR France (FR) National Cancer Institute of Thailand TH Thailand (TH) IFOM - FIRC Institute of Molecular Oncology IT Italy (IT) Fondazione IRCCS: Istituto Nazionale dei Tumori IT Italy (IT) Vanderbilt University US United States (USA) (US) Shanghai Cancer Institute / 上海市肿瘤研究所 CN China (CN) Shanghai Center For Disease Control And Prevention (SCDC) CN China (CN) Ministry of Public Health (MOPH) / กระทรวงสาธารณสุข TH Thailand (TH) University of Warwick GB United Kingdom (GB) University of Manchester GB United Kingdom (GB) University of Sheffield GB United Kingdom (GB) University of Southern California (USC) US United States (USA) (US) Kaohsiung Medical University (KMU) / 高雄醫學大學 TW Taiwan (TW) Tri-Service General Hospital (TSGH) / 三軍總醫院 TW Taiwan (TW) Academia Sinica / 中央研究院 TW Taiwan (TW) Antoni van Leeuwenhoek NL Netherlands (NL) Mount Sinai Hospital (MSH) CA Canada (CA) University of Toronto CA Canada (CA) Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung (IPA) DE Germany (DE) Robert-Bosch-Krankenhaus DE Germany (DE) National University of Singapore (NUS) SG Singapore (SG) Cancer Research Initiatives Foundation (CARIF) / Cancer Research Malaysia (CRM) MY Malaysia (MY) University of Malaya (UM) / Universiti Malaya MY Malaysia (MY) The University of Melbourne AU Australia (AU) Seoul National University (SNU) / 서울대학교 KR Korea, Republic of (KR) National University of Ireland (NUI), Galway IE Ireland (IE) University of Oxford GB United Kingdom (GB) King’s College London GB United Kingdom (GB) National University Health System (NUHS) SG Singapore (SG) Aichi Cancer Center Research Institute JP Japan (JP) Kyushu University / 九州大学 JP Japan (JP) University College London (UCL) GB United Kingdom (GB) Hospital Monte Naranco ES Spain (ES) National Cancer Institute (NCI) US United States (USA) (US) Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie PL Poland (PL) Leiden University NL Netherlands (NL) Oulun Yliopisto / University of Oulo FI Finland (FI) Université de Montréal CA Canada (CA) McGill University CA Canada (CA) Centre hospitalier universitaire de Québec CA Canada (CA) University of Hawaii (U.H.) US United States (USA) (US) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven BE Belgium (BE) Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB) BE Belgium (BE) University of Eastern Finland FI Finland (FI) Krebsregister Saarland / Saarland Cancer Registry DE Germany (DE) University of Copenhagen DK Denmark (DK) National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) FR France (FR) Research Center in Epidemiology and Population Health / Centre de recherche en Epidémiologie et Santé des Populations (CESP) FR France (FR) Ruprecht-Karls-Universität Heidelberg DE Germany (DE)

How to cite

APA:

Agarwal, D., Pineda, S., Michailidou, K., Herranz, J., Pita, G., Moreno, L.T.,... Milne, R.L. (2014). FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium. British Journal of Cancer, 110(4), 1088-100. https://dx.doi.org/10.1038/bjc.2013.769

MLA:

Agarwal, D., et al. "FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium." British Journal of Cancer 110.4 (2014): 1088-100.

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