Concentrations of matrix metalloproteinases and their tissue inhibitors in the cerebrospinal fluid of patients with Alzheimer's disease

Mroczko B, Groblewska M, Zboch M, Kulczynska A, Koper OM, Szmitkowski M, Kornhuber J, Lewczuk P (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Journal of Alzheimer's Disease IOS Press

Book Volume: 40

Pages Range: 351-7

Journal Issue: 2

DOI: 10.3233/JAD-131634

Abstract

A growing body of evidence shows the involvement of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in neurodegeneration processes, but reports of their concentrations in the cerebrospinal fluid (CSF) are inconsistent.Therefore, the aim of our study was to evaluate the CSF concentrations of MMP-2, MMP-3, MMP-9, and their inhibitors (TIMP-1 and TIMP-2) in carefully selected groups of patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and non-demented controls, whose clinical and neuropsychological diagnoses were confirmed by the corresponding CSF biomarkers of neurochemical dementia diagnostics: decreased concentrations of A?1-42 and/or A?42/40 ratio, and increased concentrations of Tau and pTau181 proteins.The study included 33 AD patients, 15 subjects with MCI, and 18 elderly individuals without cognitive deficits. The CSF concentrations of MMPs and TIMPs were determined with ELISAs.CSF concentrations of MMP-9 were significantly lower, and the concentrations of MMP-3 significantly higher in AD patients compared to the controls. Neither MMP-2 nor TIMPs showed significant changes among the groups investigated.Altered concentrations of two out of three MMPs investigated in this study suggest that this family of biomolecules may play a role in the AD pathophysiology. Further studies are needed to establish their potential diagnostic utility.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Piotr Lewczuk Department of Psychiatry and Psychotherapy

Involved external institutions

University of Białystok PL Poland (PL) Medical University of Bialystok Clinical Hospital / Uniwersytecki Szpital Kliniczny w Białymstoku PL Poland (PL) Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu PL Poland (PL)

How to cite

APA:

Mroczko, B., Groblewska, M., Zboch, M., Kulczynska, A., Koper, O.M., Szmitkowski, M.,... Lewczuk, P. (2014). Concentrations of matrix metalloproteinases and their tissue inhibitors in the cerebrospinal fluid of patients with Alzheimer's disease. Journal of Alzheimer's Disease, 40(2), 351-7. https://dx.doi.org/10.3233/JAD-131634

MLA:

Mroczko, Barbara, et al. "Concentrations of matrix metalloproteinases and their tissue inhibitors in the cerebrospinal fluid of patients with Alzheimer's disease." Journal of Alzheimer's Disease 40.2 (2014): 351-7.

BibTeX: Download