Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde
Leovac VM, Bogdanovic GA, Jovanovic LS, Joksovic L, Markovic V, Joksovic MD, Dencic SM, Isakovic A, Markovic I, Heinemann FW, Trifunovic S, Dalovic I (2011)
Publication Status: Published
Publication Type: Journal article
Publication year: 2011
Journal
Publisher: ELSEVIER SCIENCE INC
Book Volume: 105
Pages Range: 1413-1421
Journal Issue: 11
DOI: 10.1016/j.jinorgbio.2011.07.021
Abstract
New polymeric copper(II) complexes with two tridentate ONS thiosemicarbazone ligands containing substituted pyrazolone moiety were synthesized and characterized by means of spectroscopic, electrochemical and crystallographic techniques. While both ligands exist as different tautomers in the solid state and DMSO-d(6) solution, Cu(II) ion coordinates the ligands from the same tautomeric form with square-pyramidal geometry around each Cu atom. In the crystal structures, the copper(II) complex cation forms polymeric chains {[Cu(L)Cl(+)]}(n) with a bridging chlorine atom. One of the complexes was found to have a significantly higher cytotoxic potential in comparison with cisplatin in inhibition of several cell lines (HL60, REH, C6, L929 and B16). The results obtained on the basis of flow cytometry indicated that apoptosis could be possible mechanism of cell death. (C) 2011 Elsevier Inc. All rights reserved.
Authors with CRIS profile
Involved external institutions
Institute of Field and Vegetable Crops
Serbia (RS)
University of Kragujevac
Serbia (RS)
University of Belgrade / Универзитет у Београду
Serbia (RS)
University of Novi Sad
Serbia (RS)
Serbia (RS)
University of Kragujevac
Serbia (RS)
University of Belgrade / Универзитет у Београду
Serbia (RS)
University of Novi Sad
Serbia (RS)
How to cite
APA:
Leovac, V.M., Bogdanovic, G.A., Jovanovic, L.S., Joksovic, L., Markovic, V., Joksovic, M.D.,... Dalovic, I. (2011). Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde. Journal of Inorganic Biochemistry, 105(11), 1413-1421. https://doi.org/10.1016/j.jinorgbio.2011.07.021
MLA:
Leovac, Vukadin M., et al. "Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde." Journal of Inorganic Biochemistry 105.11 (2011): 1413-1421.
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