New Simple Synthesis of N-Substituted 1,3-Oxazinan-2-ones

Trifunovic S, Dimitrijevic D, Vasic G, Radulovic N, Vukicevic M, Heinemann FW, Vukicevic RD (2010)

Publication Status: Published

Publication Type: Journal article

Publication year: 2010

Journal

Synthesis-Stuttgart Thieme Publishing / Georg Thieme Verlag

Publisher: GEORG THIEME VERLAG KG

Pages Range: 943-946

Journal Issue: 6

DOI: 10.1055/s-0029-1218642

Abstract

An efficient and simple synthesis of N-substituted 1,3-oxazinan-2-ones was developed that involves a three-component, one-pot reaction of readily available tetraethylammonium bicarbonate, 1,3-dibromopropane, and a primary amine in methanol at room temperature. L-Alanine can be used as the amino component to give the chiral product (2S)-2-(2-oxo-1,3-oxazinan-3-yl)propanoic acid.

Authors with CRIS profile

Frank Wilhelm Heinemann Lehrstuhl für Anorganische und Allgemeine Chemie

Involved external institutions

University of Kragujevac RS Serbia (RS) University of Nish RS Serbia (RS)

How to cite

APA:

Trifunovic, S., Dimitrijevic, D., Vasic, G., Radulovic, N., Vukicevic, M., Heinemann, F.W., & Vukicevic, R.D. (2010). New Simple Synthesis of N-Substituted 1,3-Oxazinan-2-ones. Synthesis-Stuttgart, 6, 943-946. https://dx.doi.org/10.1055/s-0029-1218642

MLA:

Trifunovic, Srecko, et al. "New Simple Synthesis of N-Substituted 1,3-Oxazinan-2-ones." Synthesis-Stuttgart 6 (2010): 943-946.

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