The novel surfactant protein SP-H enhances the phagocytosis efficiency of macrophage-like cell lines U937 and MH-S

Diler E, Schicht M, Rabung A, Tschernig T, Meier C, Rausch F, Garreis F, Bräuer L, Paulsen F (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Book Volume: 7

Pages Range: 851

DOI: 10.1186/1756-0500-7-851

Abstract

Surfactant proteins (SP) secreted by alveolar type 2 cells, play an essential role in maintaining the air-liquid barrier of the lung and are also involved in the opsonisation and clearance of bacteria by phagocytes. We have recently described a novel surfactant protein, SP-H (SFTA3). Expression of SP-H was earlier demonstrated to be upregulated by LPS and negatively regulated by IL-1? and IL-23 in vitro. The influence of SP-H on phagocytosis was measured using a murine and a human phagocytic cell line and fluorescent latex beads.SP-H markedly increases phagocytosis in vitro in the murine-derived alveolar macrophage cell lines MH-S and in human-derived differentiated U937 cells.It can be assumed that SP-H is involved in regulating phagocytic activity of macrophages. SP-H is a new player in pulmonary host defence.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) Germany (DE)

How to cite

APA:

Diler, E., Schicht, M., Rabung, A., Tschernig, T., Meier, C., Rausch, F.,... Paulsen, F. (2014). The novel surfactant protein SP-H enhances the phagocytosis efficiency of macrophage-like cell lines U937 and MH-S. BMC Research Notes, 7, 851. https://doi.org/10.1186/1756-0500-7-851

MLA:

Diler, Ebru, et al. "The novel surfactant protein SP-H enhances the phagocytosis efficiency of macrophage-like cell lines U937 and MH-S." BMC Research Notes 7 (2014): 851.

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