The novel surfactant protein SP-H enhances the phagocytosis efficiency of macrophage-like cell lines U937 and MH-S

Journal article


Publication Details

Author(s): Diler E, Schicht M, Rabung A, Tschernig T, Meier C, Rausch F, Garreis F, Bräuer L, Paulsen F
Journal: BMC Research Notes
Publication year: 2014
Volume: 7
Pages range: 851
ISSN: 1756-0500


Abstract

Surfactant proteins (SP) secreted by alveolar type 2 cells, play an essential role in maintaining the air-liquid barrier of the lung and are also involved in the opsonisation and clearance of bacteria by phagocytes. We have recently described a novel surfactant protein, SP-H (SFTA3). Expression of SP-H was earlier demonstrated to be upregulated by LPS and negatively regulated by IL-1? and IL-23 in vitro. The influence of SP-H on phagocytosis was measured using a murine and a human phagocytic cell line and fluorescent latex beads.SP-H markedly increases phagocytosis in vitro in the murine-derived alveolar macrophage cell lines MH-S and in human-derived differentiated U937 cells.It can be assumed that SP-H is involved in regulating phagocytic activity of macrophages. SP-H is a new player in pulmonary host defence.


FAU Authors / FAU Editors

Bräuer, Lars Prof. Dr.
Professur für Oberflächenaktive Proteine
Garreis, Fabian PD Dr.
Lehrstuhl für Anatomie II
Paulsen, Friedrich Prof. Dr.
Lehrstuhl für Anatomie II
Rausch, Felix
Lehrstuhl für Anatomie II
Schicht, Martin Dr.
Lehrstuhl für Anatomie II


External institutions with authors

Universitätsklinikum des Saarlandes


How to cite

APA:
Diler, E., Schicht, M., Rabung, A., Tschernig, T., Meier, C., Rausch, F.,... Paulsen, F. (2014). The novel surfactant protein SP-H enhances the phagocytosis efficiency of macrophage-like cell lines U937 and MH-S. BMC Research Notes, 7, 851. https://dx.doi.org/10.1186/1756-0500-7-851

MLA:
Diler, Ebru, et al. "The novel surfactant protein SP-H enhances the phagocytosis efficiency of macrophage-like cell lines U937 and MH-S." BMC Research Notes 7 (2014): 851.

BibTeX: 

Last updated on 2019-24-06 at 08:48