Measurement of kidney perfusion by magnetic resonance imaging: Comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome

Ritt M, Janka RM, Schneider MP, Martirosian P, Hornegger J, Bautz W, Uder M, Schmieder R (2010)

Publication Type: Journal article, Original article

Publication year: 2010

Journal

Original Authors: Ritt M., Janka R., Schneider M., Martirosian P., Hornegger J., Bautz W., Uder M., Schmieder R.

Publisher: Oxford University Press (OUP): Policy B

Book Volume: 25

Pages Range: 1126-1133

Journal Issue: 4

DOI: 10.1093/ndt/gfp639

Abstract

Background. Magnetic resonance imaging with arterial spin labeling (MRI-ASL) is a non-invasive approach to measure organ perfusion. We aimed to examine whether MRI-ASL kidney perfusion measurements are related to measurements of renal plasma flow (RPF) by para-aminohippuric acid (PAH) plasma clearance and whether changes of kidney perfusion in response to treatment with telmisartan can be detected by MRI-ASL.Methods. Twenty-four patients with metabolic syndrome and an estimated creatinine clearance according to Cockroft and Gault of ≥60ml/min were included in the study. Kidney perfusion was assessed by MRI-ASL measurements of a single coronal kidney slice (with flow-sensitive alternating inversion recovery and true fast imaging with steady-state processing sequence) and by measurements of RPF using PAH plasma clearance before and after 2 weeks of treatment with the angiotensin receptor blocker telmisartan. All MRI-ASL examinations were performed on a 1.5 T scanner.Results. Two weeks of therapy with telmisartan led to a significant increase of RPF (from 313 ± 47 to 348 ± 69ml/min/m, P = 0.007) and MRI-ASL kidney perfusion measurements (from 253 ± 20 to 268 ± 25ml/min/100g, P = 0.020). RPF measurements were related with MRI-ASL kidney perfusion measurements (r = 0.575, P < 0.001). Changes of RPF measurements and changes of MRI-ASL kidney perfusion measurements in response to treatment with telmisartan revealed a close relationship when expressed in absolute terms (r = 0.548, P = 0.015) and in percentage changes (r = 0.514, P = 0.025).Conclusions. Perfusion measurement of a single coronal kidney slice by MRI-ASL is able to approximate kidney perfusion and to approximate changes in kidney perfusion due to pharmacological intervention. © 2009 The Author.

Authors with CRIS profile

Involved external institutions

Eberhard Karls Universität Tübingen Germany (DE)

How to cite

APA:

Ritt, M., Janka, R.M., Schneider, M.P., Martirosian, P., Hornegger, J., Bautz, W.,... Schmieder, R. (2010). Measurement of kidney perfusion by magnetic resonance imaging: Comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome. Nephrology Dialysis Transplantation, 25(4), 1126-1133. https://dx.doi.org/10.1093/ndt/gfp639

MLA:

Ritt, Martin, et al. "Measurement of kidney perfusion by magnetic resonance imaging: Comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome." Nephrology Dialysis Transplantation 25.4 (2010): 1126-1133.

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