2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Li J, Lindstroem LS, Foo JN, Rafiq S, Schmidt MK, Pharoah PDP, Michailidou K, Dennis J, Bolla MK, Wang Q, Van'T Veer LJ, Cornelissen S, Rutgers E, Southey MC, Apicella C, Dite GS, Hopper JL, Fasching P, Häberle L, Ekici AB, Beckmann M, Blomqvist C, Muranen TA, Aittomaeki K, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Hartikainen JM, Kataja V, Chenevix-Trench G, Phillips KA, Mclachlan SA, Lambrechts D, Thienpont B, Smeets A, Wildiers H, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Giles GG, Baglietto L, Severi G, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Kristensen V, Alnaes GIG, Borresen-Dale AL, Nord S, Winqvist R, Pylkas K, Jukkola-Vuorinen A, Grip M, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Devilee P, Tollenaar R, Seynaeve C, Hooning M, Kriege M, Hollestelle A, Van Den Ouweland A, Li Y, Hamann U, Torres D, Ulmer HU, Rudiger T, Shen CY, Hsiung CN, Wu PE, Chen ST, Teo SH, Taib NAM, Yip CH, Ho GF, Matsuo K, Ito H, Iwata H, Tajima K, Kang D, Choi JY, Park SK, Yoo KY, Maishman T, Tapper WJ, Dunning A, Shah M, Luben R, Brown J, Khor CC, Eccles DM, Nevanlinna H, Easton D, Humphreys K, Liu J, Hall P, Czene K
Zeitschrift: Nature Communications
Jahr der Veröffentlichung: 2014
Band: 5
Seitenbereich: 4051
ISSN: 2041-1723


Abstract


Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Ekici, Arif Bülent Dr. rer. nat.
Humangenetisches Institut
Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe


Einrichtungen weiterer Autorinnen und Autoren

Academia Sinica / 中央研究院
Aichi Cancer Center Research Institute
Cancer Research Initiatives Foundation (CARIF)
Center for Cancer Biology (CCB) (formerly Vesalius Research Center (VRC))
Changhua Christian Hospital
Deutsches Krebsforschungszentrum (DKFZ)
Erasmus University Medical Center
Erasmus University Rotterdam (EUR) / Erasmus Universiteit Rotterdam
Genome Institute of Singapore
Helsingin yliopisto / University of Helsinki
Karolinska Institute
Klinikum Mittelbaden Baden-Baden Balg
Kyushu University / 九州大学
Leiden University
Mount Sinai Hospital (MSH)
Netherlands Cancer Institute (NKI)
Oslo University Hospital / Oslo Universitetssykehus
Oulun Yliopisto / University of Oulo
QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research)
Seoul National University (SNU) / 서울대학교
Städtisches Klinikum Karlsruhe
St Vincent's Hospital
The University of Melbourne
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
University of California San Francisco (UCSF)
University of Cambridge
University of Eastern Finland
University of Hawaii (U.H.)
University of Malaya (UM) / Universiti Malaya
University of Southampton
University of Southern California (USC)


Zitierweisen

APA:
Li, J., Lindstroem, L.S., Foo, J.N., Rafiq, S., Schmidt, M.K., Pharoah, P.D.P.,... Czene, K. (2014). 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. Nature Communications, 5, 4051. https://dx.doi.org/10.1038/ncomms5051

MLA:
Li, Jingmei, et al. "2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy." Nature Communications 5 (2014): 4051.

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Zuletzt aktualisiert 2019-21-07 um 08:06