2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Li J, Lindstroem LS, Foo JN, Rafiq S, Schmidt MK, Pharoah PDP, Michailidou K, Dennis J, Bolla MK, Wang Q, Van'T Veer LJ, Cornelissen S, Rutgers E, Southey MC, Apicella C, Dite GS, Hopper JL, Fasching P, Häberle L, Ekici AB, Beckmann M, Blomqvist C, Muranen TA, Aittomaeki K, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Hartikainen JM, Kataja V, Chenevix-Trench G, Phillips KA, Mclachlan SA, Lambrechts D, Thienpont B, Smeets A, Wildiers H, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Giles GG, Baglietto L, Severi G, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Kristensen V, Alnaes GIG, Borresen-Dale AL, Nord S, Winqvist R, Pylkas K, Jukkola-Vuorinen A, Grip M, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Devilee P, Tollenaar R, Seynaeve C, Hooning M, Kriege M, Hollestelle A, Van Den Ouweland A, Li Y, Hamann U, Torres D, Ulmer HU, Rudiger T, Shen CY, Hsiung CN, Wu PE, Chen ST, Teo SH, Taib NAM, Yip CH, Ho GF, Matsuo K, Ito H, Iwata H, Tajima K, Kang D, Choi JY, Park SK, Yoo KY, Maishman T, Tapper WJ, Dunning A, Shah M, Luben R, Brown J, Khor CC, Eccles DM, Nevanlinna H, Easton D, Humphreys K, Liu J, Hall P, Czene K (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Book Volume: 5

Pages Range: 4051

DOI: 10.1038/ncomms5051

Abstract

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

Authors with CRIS profile

Involved external institutions

The University of Melbourne Australia (AU) Erasmus University Medical Center (MC) Netherlands (NL) Mount Sinai Hospital (MSH) Canada (CA) Leiden University Netherlands (NL) Erasmus University Rotterdam (EUR) / Erasmus Universiteit Rotterdam Netherlands (NL) Genome Institute of Singapore Singapore (SG) Klinikum Mittelbaden Baden-Baden Balg Germany (DE) Städtisches Klinikum Karlsruhe Germany (DE) Academia Sinica / 中央研究院 Taiwan (TW) Changhua Christian Hospital Taiwan (TW) Cancer Research Initiatives Foundation (CARIF) / Cancer Research Malaysia (CRM) Malaysia (MY) University of Malaya (UM) / Universiti Malaya Malaysia (MY) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) University of California San Francisco (UCSF) United States (USA) (US) Netherlands Cancer Institute (NKI) Netherlands (NL) Helsingin yliopisto / University of Helsinki Finland (FI) St Vincent's Hospital Australia (AU) Center for Cancer Biology (CCB) (formerly Vesalius Research Center (VRC)) Belgium (BE) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) University of Hawaii (U.H.) United States (USA) (US) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) University of Southampton United Kingdom (GB) Aichi Cancer Center Research Institute Japan (JP) Seoul National University (SNU) / 서울대학교 Korea, Republic of (KR) Karolinska Institute Sweden (SE) University of Cambridge United Kingdom (GB) Oulun Yliopisto / University of Oulo Finland (FI) University of Southern California (USC) United States (USA) (US) Kyushu University / 九州大学 Japan (JP) University of Eastern Finland Finland (FI) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU)

How to cite

APA:

Li, J., Lindstroem, L.S., Foo, J.N., Rafiq, S., Schmidt, M.K., Pharoah, P.D.P.,... Czene, K. (2014). 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. Nature Communications, 5, 4051. https://doi.org/10.1038/ncomms5051

MLA:

Li, Jingmei, et al. "2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy." Nature Communications 5 (2014): 4051.

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