Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

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Details zur Publikation

Autorinnen und Autoren: Ortega F, Gascon S, Masserdotti G, Deshpande A, Simon C, Fischer J, Dimou L, Lie DC, Schroeder T, Berninger B
Zeitschrift: Nature Cell Biology
Jahr der Veröffentlichung: 2013
Band: 15
Heftnummer: 6
Seitenbereich: 602-13
ISSN: 1465-7392


Abstract


The adult mouse subependymal zone (SEZ) harbours adult neural stem cells (aNSCs) that give rise to neuronal and oligodendroglial progeny. However it is not known whether the same aNSC can give rise to neuronal and oligodendroglial progeny or whether these distinct progenies constitute entirely separate lineages. Continuous live imaging and single-cell tracking of aNSCs and their progeny isolated from the mouse SEZ revealed that aNSCs exclusively generate oligodendroglia or neurons, but never both within a single lineage. Moreover, activation of canonical Wnt signalling selectively stimulated proliferation within the oligodendrogliogenic lineage, resulting in a massive increase in oligodendrogliogenesis without changing lineage choice or proliferation within neurogenic clones. In vivo activation or inhibition of canonical Wnt signalling respectively increased or decreased the number of Olig2 and PDGFR- ? positive cells, suggesting that this pathway contributes to the fine tuning of oligodendrogliogenesis in the adult SEZ.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Lie, Dieter Chichung Prof. Dr.
Professur für Molekulare Medizin mit dem Schwerpunkt Molekulare Bildgebung


Einrichtungen weiterer Autorinnen und Autoren

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU)
Ludwig-Maximilians-Universität (LMU)


Zitierweisen

APA:
Ortega, F., Gascon, S., Masserdotti, G., Deshpande, A., Simon, C., Fischer, J.,... Berninger, B. (2013). Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling. Nature Cell Biology, 15(6), 602-13. https://dx.doi.org/10.1038/ncb2736

MLA:
Ortega, Felipe, et al. "Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling." Nature Cell Biology 15.6 (2013): 602-13.

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